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- W2891418657 abstract "e18565 Introduction: Hydroxyurea (HU) is deemed first-line cytoreductive therapy for patients with essential thrombocythemia (ET) at high-risk for vascular complications with 20-25% of patients developing HU intolerance/ resistance (HUIR). Up to one-third of patients taking anagrelide, often the 2 nd line drug of choice, are also unable to tolerate its side effects (cardiovascular and gastrointestinal). A review of the medical literature suggests widespread support for individualized treatment plans in ET with multiple options, including HU, anagrelide, interferon and busulfan, but little is known about physician practice. Methods: We contracted with a research company to perform an internet survey of 20 academic and 20 community hematologists to assess treatment practices for HUIR ET patients. We assumed a 25% rate of resistance to anagrelide. Results: Academic and community physicians reported 22% and 25% HUIR rates, respectively. An estimated 60% and 44% of HUIR patients in academic and community settings, respectively, would undergo treatment with an agent other than anagrelide (interferon, busulfan, or ruxolitinib) in 2 nd or 3 rd line treatments. Physicians not using anagrelide as 2 nd line therapy also would not use it as 3 rd line therapy. Anagrelide is used more frequently in the community setting. Conclusions: About 50% of HUIR patients are treated with agents other than anagrelide as 2 nd / 3 rd line therapy. Reasons for practice variation in the treatment of ET remain poorly understood. [Table: see text]" @default.
- W2891418657 created "2018-09-27" @default.
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- W2891418657 date "2017-05-20" @default.
- W2891418657 modified "2023-09-26" @default.
- W2891418657 title "Treatment of essential thrombocytopenia patients intolerant/ resistant to hydroxyurea: A physician survey." @default.
- W2891418657 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e18565" @default.
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