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• W289142167 startingPage "1934578X0900401" @default.
• W289142167 abstract "From the medicinal plant Ginkgo biloba the fungal endophyte Alternaria no.28 was isolated. Extract of the fungus grown in liquid culture media exhibited marked cytotoxic activity when tested in vitro against brine shrimp (Artemia salina). Eight compounds were isolated from the extract of cultures of this endophytic fungus and were elucidated as alterperylenol (1), altertoxin I (2), alternariol (3), alternariol monomethyl ether (4), tenuazonic acid (5) and its derivative (6), together with ergosterol and ergosta-4, 6, 8, 22-tetraen-3-one by means of spectroscopic analysis. Among them, both 5 and 6 showed significant cytotoxic effects in the brine shrimp bioassy, with mortality rates of 73.6% and 68.9%, respectively, at a concentration of 10 microg x mL(-1), and they were first isolated from endophytic fungi." @default.
• W289142167 created "2016-06-24" @default.
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• W289142167 date "2009-11-01" @default.
• W289142167 modified "2023-10-16" @default.
• W289142167 title "Cytotoxic Metabolites Produced by <i>Alternaria</i> No.28, an Endophytic Fungus Isolated from <i>Ginkgo biloba</i>" @default.
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• W289142167 doi "https://doi.org/10.1177/1934578x0900401106" @default.
• W289142167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19967976" @default.
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