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- W2891422918 abstract "Viable gamete formation requires segregation of homologous chromosomes connected, in most species, by cross-overs. DNA double-strand break (DSB) formation and the resulting cross-overs are regulated at multiple levels to prevent overabundance along chromosomes. Meiotic cells coordinate these events between distant sites, but the physical basis of long-distance chromosomal communication has been unknown. We show that DSB hotspots up to ∼200 kb (∼35 cM) apart form clusters via hotspot-binding proteins Rec25 and Rec27 in fission yeast. Clustering coincides with hotspot competition and interference over similar distances. Without Tel1 (an ATM tumor-suppressor homolog), DSB and crossover interference become negative, reflecting coordinated action along a chromosome. These results indicate that DSB hotspots within a limited chromosomal region and bound by their protein determinants form a clustered structure that, via Tel1, allows only one DSB per region. Such a “roulette” process within clusters explains the observed pattern of crossover interference in fission yeast. Key structural and regulatory components of clusters are phylogenetically conserved, suggesting conservation of this vital regulation. Based on these observations, we propose a model and discuss variations in which clustering and competition between DSB sites leads to DSB interference and in turn produces crossover interference." @default.
- W2891422918 created "2018-09-27" @default.
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- W2891422918 date "2018-09-14" @default.
- W2891422918 modified "2023-10-16" @default.
- W2891422918 title "Physical basis for long-distance communication along meiotic chromosomes" @default.
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- W2891422918 doi "https://doi.org/10.1073/pnas.1801920115" @default.
- W2891422918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6176642" @default.
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