FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891425021> ?p ?o ?g. }

• W2891425021 endingPage "64" @default.
• W2891425021 startingPage "56" @default.
• W2891425021 abstract "The vitamin A derivative 9-cis-retinoic acid (9-cis-RA) has been used for the treatment and prevention of cutaneous T-cell lymphoma (CTCL). However, the precise mechanism by which 9-cis-RA treatment ameliorates CTCL remains elusive. Our research shows that 9-cis-RA inhibits proliferation and induces apoptosis in CTCL cells in a dose-dependent and time-dependent manner. 9-Cis-RA also induced G0/G1 cell cycle arrest by downregulation of cyclin D1. We confirmed that 9-cis-RA significantly decreased phosphorylation of JAK1, STAT3, and STAT5 and downregulated Bcl-xL and cyclin D1, indicating that 9-cis-RA inhibited the activation of JAK/STAT signaling. Meanwhile, 9-cis-RA also activated classical RA-mediated transcription by retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) in a CTCL cell line. Thus, 9-cis-RA may be effective for chemotherapy and may prevent human CTCL by inhibiting proliferation and inducing apoptosis by inhibition of the JAK/STAT pathway and activation of the RAR/RXR pathway." @default.
• W2891425021 created "2018-09-27" @default.
• W2891425021 creator A5013017488 @default.
• W2891425021 creator A5013105228 @default.
• W2891425021 creator A5033548655 @default.
• W2891425021 creator A5048341394 @default.
• W2891425021 creator A5071820359 @default.
• W2891425021 creator A5074823547 @default.
• W2891425021 date "2019-01-01" @default.
• W2891425021 modified "2023-10-05" @default.
• W2891425021 title "Effects of 9-cis-retinoic acid on the proliferation and apoptosis of cutaneous T-cell lymphoma cells" @default.
• W2891425021 cites W181079302 @default.
• W2891425021 cites W1964100132 @default.
• W2891425021 cites W1991205310 @default.
• W2891425021 cites W2006491285 @default.
• W2891425021 cites W2007792721 @default.
• W2891425021 cites W2023789884 @default.
• W2891425021 cites W2042904359 @default.
• W2891425021 cites W2074945496 @default.
• W2891425021 cites W2100387329 @default.
• W2891425021 cites W2134540087 @default.
• W2891425021 cites W2147828628 @default.
• W2891425021 cites W2152393285 @default.
• W2891425021 cites W2162357150 @default.
• W2891425021 cites W2172133051 @default.
• W2891425021 cites W2185950862 @default.
• W2891425021 cites W2246163271 @default.
• W2891425021 cites W2271138696 @default.
• W2891425021 cites W2347152249 @default.
• W2891425021 cites W2510898089 @default.
• W2891425021 cites W2587452917 @default.
• W2891425021 cites W2752699330 @default.
• W2891425021 cites W2761451453 @default.
• W2891425021 cites W2765353749 @default.
• W2891425021 cites W4249660526 @default.
• W2891425021 doi "https://doi.org/10.1097/cad.0000000000000692" @default.
• W2891425021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198914" @default.
• W2891425021 hasPublicationYear "2019" @default.
• W2891425021 type Work @default.
• W2891425021 sameAs 2891425021 @default.
• W2891425021 citedByCount "8" @default.
• W2891425021 countsByYear W28914250212021 @default.
• W2891425021 countsByYear W28914250212022 @default.
• W2891425021 crossrefType "journal-article" @default.
• W2891425021 hasAuthorship W2891425021A5013017488 @default.
• W2891425021 hasAuthorship W2891425021A5013105228 @default.
• W2891425021 hasAuthorship W2891425021A5033548655 @default.
• W2891425021 hasAuthorship W2891425021A5048341394 @default.
• W2891425021 hasAuthorship W2891425021A5071820359 @default.
• W2891425021 hasAuthorship W2891425021A5074823547 @default.
• W2891425021 hasConcept C104317684 @default.
• W2891425021 hasConcept C128821507 @default.
• W2891425021 hasConcept C157333092 @default.
• W2891425021 hasConcept C185592680 @default.
• W2891425021 hasConcept C190283241 @default.
• W2891425021 hasConcept C199835354 @default.
• W2891425021 hasConcept C203014093 @default.
• W2891425021 hasConcept C2775954498 @default.
• W2891425021 hasConcept C2776780870 @default.
• W2891425021 hasConcept C2777756187 @default.
• W2891425021 hasConcept C2779338263 @default.
• W2891425021 hasConcept C2779391668 @default.
• W2891425021 hasConcept C2781121885 @default.
• W2891425021 hasConcept C29537977 @default.
• W2891425021 hasConcept C42362537 @default.
• W2891425021 hasConcept C502942594 @default.
• W2891425021 hasConcept C54355233 @default.
• W2891425021 hasConcept C55493867 @default.
• W2891425021 hasConcept C62112901 @default.
• W2891425021 hasConcept C62478195 @default.
• W2891425021 hasConcept C63932345 @default.
• W2891425021 hasConcept C81885089 @default.
• W2891425021 hasConcept C86339819 @default.
• W2891425021 hasConcept C86803240 @default.
• W2891425021 hasConcept C95444343 @default.
• W2891425021 hasConceptScore W2891425021C104317684 @default.
• W2891425021 hasConceptScore W2891425021C128821507 @default.
• W2891425021 hasConceptScore W2891425021C157333092 @default.
• W2891425021 hasConceptScore W2891425021C185592680 @default.
• W2891425021 hasConceptScore W2891425021C190283241 @default.
• W2891425021 hasConceptScore W2891425021C199835354 @default.
• W2891425021 hasConceptScore W2891425021C203014093 @default.
• W2891425021 hasConceptScore W2891425021C2775954498 @default.
• W2891425021 hasConceptScore W2891425021C2776780870 @default.
• W2891425021 hasConceptScore W2891425021C2777756187 @default.
• W2891425021 hasConceptScore W2891425021C2779338263 @default.
• W2891425021 hasConceptScore W2891425021C2779391668 @default.
• W2891425021 hasConceptScore W2891425021C2781121885 @default.
• W2891425021 hasConceptScore W2891425021C29537977 @default.
• W2891425021 hasConceptScore W2891425021C42362537 @default.
• W2891425021 hasConceptScore W2891425021C502942594 @default.
• W2891425021 hasConceptScore W2891425021C54355233 @default.
• W2891425021 hasConceptScore W2891425021C55493867 @default.
• W2891425021 hasConceptScore W2891425021C62112901 @default.
• W2891425021 hasConceptScore W2891425021C62478195 @default.
• W2891425021 hasConceptScore W2891425021C63932345 @default.
• W2891425021 hasConceptScore W2891425021C81885089 @default.
• W2891425021 hasConceptScore W2891425021C86339819 @default.

• next