FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891426600> ?p ?o ?g. }

• W2891426600 endingPage "469" @default.
• W2891426600 startingPage "459" @default.
• W2891426600 abstract "Abstract Mucinous ovarian tumors (MOTs) morphologically and epidemiologically resemble mucinous cystic neoplasms (MCNs) of the pancreas, sharing a similar stroma and both occurring disproportionately among young females. Additionally, MOTs and MCNs share similar clinical characteristics and immunohistochemical phenotypes. Exome sequencing has revealed frequent recurrent mutations in KRAS and RNF43 in both MOTs and MCNs. The cell of origin for these tumors remains unclear, but MOTs sometimes arise in the context of mature cystic teratomas and other primordial germ cell (PGC) tumors. We undertook the present study to investigate whether non‐teratoma‐associated MOTs and MCNs share a common cell of origin. Comparisons of the gene expression profiles of MOTs [including both the mucinous borderline ovarian tumors (MBOTs) and invasive mucinous ovarian carcinomas (MOCs)], high‐grade serous ovarian carcinomas, ovarian surface epithelium, Fallopian tube epithelium, normal pancreatic tissue, pancreatic duct adenocarcinomas, MCNs, and single‐cell RNA‐sequencing of PGCs revealed that both MOTs and MCNs are more closely related to PGCs than to either eutopic epithelial tumors or normal epithelia. We hypothesize that MCNs may arise from PGCs that stopped in the dorsal pancreas during their descent to the gonads during early human embryogenesis, while MOTs arise from PGCs in the ovary. Together, these data suggest a common pathway for the development of MCNs and MOTs, and suggest that these tumors may be more properly classified as germ cell tumor variants. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
• W2891426600 created "2018-09-27" @default.
• W2891426600 creator A5003437490 @default.
• W2891426600 creator A5004974070 @default.
• W2891426600 creator A5007257045 @default.
• W2891426600 creator A5009987380 @default.
• W2891426600 creator A5027134730 @default.
• W2891426600 creator A5029513145 @default.
• W2891426600 creator A5041949818 @default.
• W2891426600 creator A5050099661 @default.
• W2891426600 creator A5057282543 @default.
• W2891426600 creator A5061569119 @default.
• W2891426600 creator A5061753517 @default.
• W2891426600 creator A5065593057 @default.
• W2891426600 creator A5065899382 @default.
• W2891426600 creator A5069288361 @default.
• W2891426600 creator A5071793325 @default.
• W2891426600 creator A5079599874 @default.
• W2891426600 creator A5081561534 @default.
• W2891426600 creator A5082234329 @default.
• W2891426600 creator A5087999591 @default.
• W2891426600 date "2018-10-19" @default.
• W2891426600 modified "2023-10-17" @default.
• W2891426600 title "Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors" @default.
• W2891426600 cites W1508097413 @default.
• W2891426600 cites W1577577364 @default.
• W2891426600 cites W1966266264 @default.
• W2891426600 cites W1972040499 @default.
• W2891426600 cites W1972310993 @default.
• W2891426600 cites W1979978607 @default.
• W2891426600 cites W1982982317 @default.
• W2891426600 cites W1996667997 @default.
• W2891426600 cites W2008083733 @default.
• W2891426600 cites W2012055544 @default.
• W2891426600 cites W2012736865 @default.
• W2891426600 cites W2013107316 @default.
• W2891426600 cites W2014920648 @default.
• W2891426600 cites W2017567241 @default.
• W2891426600 cites W2023210471 @default.
• W2891426600 cites W2044618001 @default.
• W2891426600 cites W2062696188 @default.
• W2891426600 cites W2063562637 @default.
• W2891426600 cites W2071014344 @default.
• W2891426600 cites W2088341616 @default.
• W2891426600 cites W2092021191 @default.
• W2891426600 cites W2116145684 @default.
• W2891426600 cites W2116634113 @default.
• W2891426600 cites W2116650193 @default.
• W2891426600 cites W2118017182 @default.
• W2891426600 cites W2128457258 @default.
• W2891426600 cites W2137232121 @default.
• W2891426600 cites W2138890144 @default.
• W2891426600 cites W2141555443 @default.
• W2891426600 cites W2146512944 @default.
• W2891426600 cites W2159081763 @default.
• W2891426600 cites W2166607774 @default.
• W2891426600 cites W2169511366 @default.
• W2891426600 cites W2170552969 @default.
• W2891426600 cites W2170989872 @default.
• W2891426600 cites W2314859868 @default.
• W2891426600 cites W2585568219 @default.
• W2891426600 cites W2767122952 @default.
• W2891426600 cites W2954674604 @default.
• W2891426600 cites W3021900411 @default.
• W2891426600 doi "https://doi.org/10.1002/path.5161" @default.
• W2891426600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240919" @default.
• W2891426600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229909" @default.
• W2891426600 hasPublicationYear "2018" @default.
• W2891426600 type Work @default.
• W2891426600 sameAs 2891426600 @default.
• W2891426600 citedByCount "21" @default.
• W2891426600 countsByYear W28914266002019 @default.
• W2891426600 countsByYear W28914266002020 @default.
• W2891426600 countsByYear W28914266002021 @default.
• W2891426600 countsByYear W28914266002022 @default.
• W2891426600 countsByYear W28914266002023 @default.
• W2891426600 crossrefType "journal-article" @default.
• W2891426600 hasAuthorship W2891426600A5003437490 @default.
• W2891426600 hasAuthorship W2891426600A5004974070 @default.
• W2891426600 hasAuthorship W2891426600A5007257045 @default.
• W2891426600 hasAuthorship W2891426600A5009987380 @default.
• W2891426600 hasAuthorship W2891426600A5027134730 @default.
• W2891426600 hasAuthorship W2891426600A5029513145 @default.
• W2891426600 hasAuthorship W2891426600A5041949818 @default.
• W2891426600 hasAuthorship W2891426600A5050099661 @default.
• W2891426600 hasAuthorship W2891426600A5057282543 @default.
• W2891426600 hasAuthorship W2891426600A5061569119 @default.
• W2891426600 hasAuthorship W2891426600A5061753517 @default.
• W2891426600 hasAuthorship W2891426600A5065593057 @default.
• W2891426600 hasAuthorship W2891426600A5065899382 @default.
• W2891426600 hasAuthorship W2891426600A5069288361 @default.
• W2891426600 hasAuthorship W2891426600A5071793325 @default.
• W2891426600 hasAuthorship W2891426600A5079599874 @default.
• W2891426600 hasAuthorship W2891426600A5081561534 @default.
• W2891426600 hasAuthorship W2891426600A5082234329 @default.
• W2891426600 hasAuthorship W2891426600A5087999591 @default.
• W2891426600 hasBestOaLocation W28914266001 @default.
• W2891426600 hasConcept C104317684 @default.

• next