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• W2891427243 abstract "Dietary interventions may effectively control cancer development, with phytosterols (PS) being a class of cancer chemopreventive dietary phytochemicals. The present study, for the first time, evaluates the antiproliferative effects of a PS-ingredient used for the enrichment of several foods and its main PS, β-sitosterol, at physiological serum levels, in the most prevalent cancer cells in women (breast (MCF-7), colon (HCT116) and cervical (HeLa)). In all three cell lines, these compounds induced significant cell viability reduction without a clear time- and dose-dependent response. Moreover, all treatments produced apoptotic cell death with the induction of DNA fragmentation through the appearance of a sub-G1 cell population. Thus, the use of PS as functional ingredients in the development of PS-enriched foods could exert a potential preventive effect against human breast, colon and cervical cancer, although further in vivo studies are required to confirm our preclinical findings." @default.
• W2891427243 created "2018-09-27" @default.
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• W2891427243 date "2018-09-07" @default.
• W2891427243 modified "2023-10-16" @default.
• W2891427243 title "Apoptotic effect of a phytosterol-ingredient and its main phytosterol (β-sitosterol) in human cancer cell lines" @default.
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• W2891427243 doi "https://doi.org/10.1080/09637486.2018.1511689" @default.
• W2891427243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192685" @default.
• W2891427243 hasPublicationYear "2018" @default.
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