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- W2891428807 abstract "The advances in pharmaceutical technology allow for the development of various region-selective delivery systems for oral administration to optimize local and systemic therapy. In this paper, micronization associated with a polymorph modification approach was proposed for improving the solubility of hydrophobic drugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or intermolecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance but also hindered the premature drug release at undesired sites..." @default.
- W2891428807 created "2018-09-27" @default.
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- W2891428807 date "2018-09-05" @default.
- W2891428807 modified "2023-10-15" @default.
- W2891428807 title "Self-Assembly of Zein-Based Microcarrier System for Colon-Targeted Oral Drug Delivery" @default.
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- W2891428807 doi "https://doi.org/10.1021/acs.iecr.8b02092" @default.
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