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- W2891431438 abstract "e16013 Background: The purpose of the study was a comparative assessment of parameters of the local cellular immunity in patients with esophageal tumors of various stages. Methods: We studied tissues of tumors, peritumoral (PT) and resection line (RL) tissues of 35 patients who underwent surgery for esophageal cancer (11 women and 24 men aged 32-76 years). All patients had squamous cell carcinoma: stage I – 7, stage II – 12, and stage III – 16 patients. Subpopulations of lymphocytes were determined in tissue homogenates using the BD FACSCantoII flow cytometer with a panel of antibodies T-, B-, NK (CD45, CD3, CD4, CD8, CD19, CD16/56); levels of T-regs (CD4+CD25+CD127dim) were assessed. Percentages of lymphocytes were calculated from the total lymphocyte number, T-regs – from the number of CD3+CD4+ cells. Tissue levels of TNF-α, IL-1ß, IL-6, IL-8 and IL-10 were determined by ELISA (pg/mL per 1 g of protein). Results: More advanced-stage tumors were characterized by statistically significant changes in lymphocyte and cytokine tumor microenvironment. The СD3+CD4+ content in st. III tumors was lower than in st. I (38.3±3.99 vs. 48±2.4%; p < 0.05); the number of СD19+ cells was 4 times lower in st. II tumors, compared to st. I (2.45±1.2 vs. 9.95±3.0%). Levels of T-regs in tumors were high ( > 20%), starting with st. I, exceeding the values in RL by 6 times and in PT by 4 times. Levels of NK cells in all tumors were 2.7 times lower compared to RL. Specific levels of cytokines in the tumor and partly in PT and LR statistically significantly increased in st. III. IL-10 in st. III tumors was 4.17±0.8 vs. 1.99±0.7 pg/mL/g in st. II, IL-1ß – 70.0±14.4 vs. 38.95±5.0 pg/mL/g, and TNF-α – 5.38±0.90 vs. 3.21±0.4 pg/mL/g, respectively (p < 0.05 in all cases). Conclusions: More advanced-stage tumors were characterized by increasing changes in their immunological microenvironment, including the deepening of T-lymphocytic and cytokine imbalances in tumor tissue with partial involvement of the peritumoral zone and resection line tissues." @default.
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- W2891431438 date "2018-05-20" @default.
- W2891431438 modified "2023-09-25" @default.
- W2891431438 title "Factors of local immunity in esophageal tumors of various stages." @default.
- W2891431438 doi "https://doi.org/10.1200/jco.2018.36.15_suppl.e16013" @default.
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