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- W289143488 abstract "A multicompartment zinc model was used to calculate cumulated activities for zinc-63 (T 1/2 = 38.1 m) and zinc-65 (T 1/2 = 244.1 d) given by intravenous (IV), oral and jejunum (enteral tube) administration routes. The model dramatically facilitates such calculations since only the initial conditions are changed. The cumulated activities were obtained for 8 anatomically defined regions by appropriate combinations of model compartments. Because the ovaries are especially important for risk assessment and were not resolved by the model, the 11 day liver-to-ovary ratio and the model derived total-body kinetics were assumed. The power of a model approach to radiation dosimetry is brought out very clearly by inspection of the Zn-63 results for stomach wall which show variations for route of administration from 1 to 3 mrads/mCi Zn-63 for IV or tube administration to 2.7 rads for oral administration. The dose to the liver drops from 500 mrads fo IV administration to 140 mrads by tube and 100 mrads orally. Gonad (24-31 mrads) and average body doses (26 mrads) are similar to each other and as would be expected show little variation with route of administration. The ability to estimate radiation doses to the region of the jejunum priormore » to any such experiments is illustrated by this work.« less" @default.
- W289143488 created "2016-06-24" @default.
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- W289143488 date "1984-01-01" @default.
- W289143488 modified "2023-09-22" @default.
- W289143488 title "Radiation dosimetry for zinc-63 for IV, oral and jejunal tube administration using a compartment model" @default.
- W289143488 hasPublicationYear "1984" @default.
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