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- W2891435420 endingPage "344" @default.
- W2891435420 startingPage "344" @default.
- W2891435420 abstract "In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required. A cell-stress response pathway, the unfolded protein response (UPR), has emerged as a promising target for the development of novel breast cancer treatments. This pathway is activated in response to a disturbance in endoplasmic reticulum (ER) homeostasis but has diverse physiological and disease-specific functions. In breast cancer, UPR signalling promotes a malignant phenotype and can confer tumours with resistance to widely used therapies. Here, we review several roles for UPR signalling in breast cancer, highlighting UPR-mediated therapy resistance and the potential for targeting the UPR alone or in combination with existing therapies." @default.
- W2891435420 created "2018-09-27" @default.
- W2891435420 creator A5019012954 @default.
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- W2891435420 creator A5075855591 @default.
- W2891435420 date "2018-09-21" @default.
- W2891435420 modified "2023-10-15" @default.
- W2891435420 title "The Unfolded Protein Response in Breast Cancer" @default.
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