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- W2891438911 abstract "Objective Treat‐to‐target (TTT) is an accepted paradigm for care of patients with rheumatoid arthritis (RA). Because TTT can be associated with more medication switches, concerns arise regarding whether implementing TTT may increase adverse events and/or resource use. The aim of this study was to examine adverse events and resource use during the preintervention and intervention periods of the TTT intervention trial. Methods We used data from 6 practices enrolled in an 18‐month cluster‐randomized controlled trial to compare adverse events and resource use before (months 1–9) and during (months 10–18) a TTT intervention. The outcomes of interest, adverse events and resource use, were based on medical record review of all rheumatology visits for RA patients before and during the intervention. Results We examined records for 321 patients before the intervention and 315 during the intervention. An adverse event was recorded in 10.2% of visits before the intervention and 8.8% of visits during the intervention ( P = 0.41). Biologic disease‐modifying antirheumatic drugs were taken by 53.6% of patients before the intervention and 49.8% of patients during the intervention ( P = 0.73). Rheumatology visits were more frequent before the intervention (mean ± SD 4.0 ± 1.4) than during the intervention (mean ± SD 3.6 ± 1.2; P = 0.02). More visits were accompanied by monitoring laboratory tests before the intervention (90.0%) compared with during the intervention (52.7%; P < 0.001). A greater percentage of visits before the intervention included diagnostic imaging (15.4%) versus during the intervention (8.9%; P < 0.001). Conclusion We observed similar rates of adverse events before and during the implementation of TTT for RA. Rheumatology visits, use of laboratory monitoring, and diagnostic imaging did not increase during the TTT intervention." @default.
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- W2891438911 date "2019-07-19" @default.
- W2891438911 modified "2023-10-12" @default.
- W2891438911 title "Adverse Events and Resource Use Before and After Treat‐to‐Target in Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial" @default.
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- W2891438911 doi "https://doi.org/10.1002/acr.23755" @default.
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