FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891440387> ?p ?o ?g. }

• W2891440387 endingPage "974" @default.
• W2891440387 startingPage "970" @default.
• W2891440387 abstract "This study investigates the effect of epigallocatechin-3-gallate (EGCG), a major ingredient of green tea, on the pharmacokinetics of amlodipine in rats.The pharmacokinetics of orally administered amlodipine (1 mg/kg) with or without EGCG pretreatment (30 mg/kg/day for 10 days) were investigated. Plasma concentrations of amlodipine were determined by using a sensitive and reliable liquid chromatography with tandem mass spectroscopy (LC-MS/MS) method. The effects of EGCG on the metabolic stability of amlodipine were investigated by using rat liver microsome incubation systems.The results indicated that when the rats were pretreated with EGCG, the Cmax of amlodipine increased from 16.32 ± 2.57 to 21.44 ± 3.56 ng/mL (p < 0.05), the Tmax decreased from 5.98 ± 1.25 to 4.01 ± 1.02 h (p < 0.05), and the AUC0–t increased from 258.12 ± 76.25 to 383.34 ± 86.95 μg h L−1 (p < 0.05), which suggested that the pharmacokinetic behavior of amlodipine was affected after oral co-administration of EGCG. Additionally, the metabolic half-life was prolonged from 31.3 ± 5.6 to 52.6 ± 7.9 min (p < 0.05) with the pretreatment of EGCG.It can be speculated that the drug-drug interaction between EGCG and amlodipine might occur, which might have resulted from the metabolism inhibition of amlodipine by EGCG when they were co-administered." @default.
• W2891440387 created "2018-09-27" @default.
• W2891440387 creator A5030446424 @default.
• W2891440387 creator A5035590977 @default.
• W2891440387 creator A5035682541 @default.
• W2891440387 creator A5058753230 @default.
• W2891440387 creator A5078939665 @default.
• W2891440387 creator A5087309857 @default.
• W2891440387 date "2018-10-16" @default.
• W2891440387 modified "2023-10-15" @default.
• W2891440387 title "Effect Of epigallocatechin-3-gallate on the pharmacokinetics of amlodipine in rats" @default.
• W2891440387 cites W1214436714 @default.
• W2891440387 cites W1244992994 @default.
• W2891440387 cites W1964639243 @default.
• W2891440387 cites W1996504894 @default.
• W2891440387 cites W2013335354 @default.
• W2891440387 cites W2017325092 @default.
• W2891440387 cites W2041248713 @default.
• W2891440387 cites W2042421971 @default.
• W2891440387 cites W2043384854 @default.
• W2891440387 cites W2044203833 @default.
• W2891440387 cites W2046227111 @default.
• W2891440387 cites W2067266295 @default.
• W2891440387 cites W2072673226 @default.
• W2891440387 cites W2096983446 @default.
• W2891440387 cites W2105478893 @default.
• W2891440387 cites W2117325608 @default.
• W2891440387 cites W2119302521 @default.
• W2891440387 cites W2121994801 @default.
• W2891440387 cites W2132220387 @default.
• W2891440387 cites W2147790375 @default.
• W2891440387 cites W2148658259 @default.
• W2891440387 cites W2151695776 @default.
• W2891440387 cites W2170676717 @default.
• W2891440387 cites W2312319804 @default.
• W2891440387 cites W2313939937 @default.
• W2891440387 cites W2342374551 @default.
• W2891440387 cites W2344917874 @default.
• W2891440387 cites W2461042960 @default.
• W2891440387 cites W2474172802 @default.
• W2891440387 cites W2606976357 @default.
• W2891440387 cites W2613219517 @default.
• W2891440387 cites W2623224637 @default.
• W2891440387 cites W2623463380 @default.
• W2891440387 cites W2743593955 @default.
• W2891440387 cites W2771508544 @default.
• W2891440387 cites W2792371826 @default.
• W2891440387 cites W2811101308 @default.
• W2891440387 doi "https://doi.org/10.1080/00498254.2018.1519732" @default.
• W2891440387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30182817" @default.
• W2891440387 hasPublicationYear "2018" @default.
• W2891440387 type Work @default.
• W2891440387 sameAs 2891440387 @default.
• W2891440387 citedByCount "12" @default.
• W2891440387 countsByYear W28914403872019 @default.
• W2891440387 countsByYear W28914403872020 @default.
• W2891440387 countsByYear W28914403872021 @default.
• W2891440387 countsByYear W28914403872022 @default.
• W2891440387 countsByYear W28914403872023 @default.
• W2891440387 crossrefType "journal-article" @default.
• W2891440387 hasAuthorship W2891440387A5030446424 @default.
• W2891440387 hasAuthorship W2891440387A5035590977 @default.
• W2891440387 hasAuthorship W2891440387A5035682541 @default.
• W2891440387 hasAuthorship W2891440387A5058753230 @default.
• W2891440387 hasAuthorship W2891440387A5078939665 @default.
• W2891440387 hasAuthorship W2891440387A5087309857 @default.
• W2891440387 hasConcept C112705442 @default.
• W2891440387 hasConcept C134018914 @default.
• W2891440387 hasConcept C181199279 @default.
• W2891440387 hasConcept C185592680 @default.
• W2891440387 hasConcept C22979827 @default.
• W2891440387 hasConcept C2777192995 @default.
• W2891440387 hasConcept C2778004101 @default.
• W2891440387 hasConcept C2779431889 @default.
• W2891440387 hasConcept C2779646130 @default.
• W2891440387 hasConcept C2780295536 @default.
• W2891440387 hasConcept C55493867 @default.
• W2891440387 hasConcept C70899900 @default.
• W2891440387 hasConcept C71924100 @default.
• W2891440387 hasConcept C84393581 @default.
• W2891440387 hasConcept C87644729 @default.
• W2891440387 hasConcept C98274493 @default.
• W2891440387 hasConceptScore W2891440387C112705442 @default.
• W2891440387 hasConceptScore W2891440387C134018914 @default.
• W2891440387 hasConceptScore W2891440387C181199279 @default.
• W2891440387 hasConceptScore W2891440387C185592680 @default.
• W2891440387 hasConceptScore W2891440387C22979827 @default.
• W2891440387 hasConceptScore W2891440387C2777192995 @default.
• W2891440387 hasConceptScore W2891440387C2778004101 @default.
• W2891440387 hasConceptScore W2891440387C2779431889 @default.
• W2891440387 hasConceptScore W2891440387C2779646130 @default.
• W2891440387 hasConceptScore W2891440387C2780295536 @default.
• W2891440387 hasConceptScore W2891440387C55493867 @default.
• W2891440387 hasConceptScore W2891440387C70899900 @default.
• W2891440387 hasConceptScore W2891440387C71924100 @default.
• W2891440387 hasConceptScore W2891440387C84393581 @default.
• W2891440387 hasConceptScore W2891440387C87644729 @default.
• W2891440387 hasConceptScore W2891440387C98274493 @default.

• next