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• W2891444039 abstract "Three magneto-plasmonic nanohybrids were synthesized using Au- and Ag-coated Fe3O4 nanoparticles (NPs)-modified dual pH- and temperature-responsive triblock copolymer of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) to serve as drug carriers with potential of using in both photothermal and controlled/targeted chemotherapies. The internal superparamagnetic core gives the carriers targeted-delivery characteristics, and surface plasmon resonance-based noble metallic Au/Ag shells give them on-demand photothermal and photo-triggering release properties. To investigate the effect of coating method on the targeting property of synthesized carriers, Au NPs were attached to the magnetic core by 2 different direct/indirect procedures and the properties of the synthesized carriers including swelling ratio and thermal and optical sensitivity and switching were comprehensively investigated in 2 different buffer solutions with pH 5.5 and 7.4 at 37°C. Letrozole was used as a model anticancer drug and its loading and release properties were evaluated for the four nanocarriers. The cytotoxicity of drug-free and letrozole-loaded nanocarriers on normal L929 fibroblast and MDAMB 231 breast cancer cell lines was evaluated in absence/presence of laser radiation. The results revealed that the carriers have the potential of serving as switchable trimodal light/temperature/pH-triggered and targeted/controlled drug delivery platforms for chemophotothermal therapy." @default.
• W2891444039 created "2018-09-27" @default.
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• W2891444039 date "2018-12-01" @default.
• W2891444039 modified "2023-09-27" @default.
• W2891444039 title "Remote Trice Light, Temperature, and pH-actuation of Switchable Magneto-Plasmonic Nanocarriers for Combinational Photothermal and Controlled/Targeted Chemotherapies" @default.
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• W2891444039 doi "https://doi.org/10.1016/j.xphs.2018.08.021" @default.
• W2891444039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194958" @default.
• W2891444039 hasPublicationYear "2018" @default.
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