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• W2891444654 abstract "Objectives To investigate men’s values and preferences regarding prostate-specific antigen (PSA)-based screening for prostate cancer. Design Systematic review. Data sources We searched MEDLINE, EMBASE, PsycINFO and grey literature up to 2 September 2017. Eligibility criteria Primary studies of men’s values and preferences regarding the benefits and harms of PSA screening. Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with a modified version of a risk of bias tool for values and preferences studies, the International Patient Decision Aid Standards instrument V.3 and the Cochrane Collaboration risk of bias tool. Results We identified 4172 unique citations, of which 11 studies proved eligible. Five studies investigated PSA screening using a direct choice study design, whereas six used decisions aids displaying patient-important outcomes. The direct choice studies used different methodologies and varied considerably in the reporting of outcomes. Two studies suggested that men were willing to forego screening with a small benefit in prostate cancer mortality if it would decrease the likelihood of unnecessary treatment or biopsies. In contrast, one study reported that men were willing to accept a substantial overdiagnosis to reduce their risk of prostate cancer mortality. Among the six studies involving decision aids, willingness to undergo screening varied substantially from 37% when displaying a hypothetical reduction in mortality of 10 per 1000 men, to 44% when displaying a reduction in mortality of 7 per 1000. We found no studies that specifically investigated whether values and preferences differed among men with family history, of African descent or with lower socioeconomic levels. Conclusion The variability of men’s values and preferences reflect that the decision to screen is highly preference sensitive. Our review highlights the need for shared decision making in men considering prostate cancer screening. Trial registration number CRD42018095585." @default.
• W2891444654 created "2018-09-27" @default.
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• W2891444654 date "2018-09-01" @default.
• W2891444654 modified "2023-09-23" @default.
• W2891444654 title "Values and preferences of men for undergoing prostate-specific antigen screening for prostate cancer: a systematic review" @default.
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• W2891444654 doi "https://doi.org/10.1136/bmjopen-2018-025470" @default.
• W2891444654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129096" @default.
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