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- W2891446208 abstract "Although autophagy generally acts as a protective function in cardiomyocytes (CMs), uncontrolled or excessive activation of autophagy can be detrimental to CMs under some conditions. However, whether autophagy mediates cell death for CMs remains largely unknown. Recently, it has been shown in HeLa cells that excessive activation of autophagy induces cell death with characteristic morphological and biochemical features, and this form of cell death is termed autosis. Here we investigated whether death of CMs is induced by autosis in the presence of TAT-Beclin1, an autophagy-inducing peptide, and ischemia/reperfusion. TAT-Beclin1 treatment dose-dependently increased the level of LC3-II and decreased that of p62. TAT-Beclin1-treated CMs showed increases in trypan-blue-positive cells suggesting that autophagy-related cell death is induced by TAT-Beclin1. TAT-Beclin1-treated CMs showed the typical morphological features of autosis, including increased autophagic vacuoles and empty vacuoles, perinuclear spaces w..." @default.
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- W2891446208 date "2017-07-21" @default.
- W2891446208 modified "2023-09-23" @default.
- W2891446208 title "Abstract 359: Autosis is Triggered by Ischemia/Reperfusion in the Heart" @default.
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