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• W2891449152 abstract "The mammalian neocortex is composed of many types of excitatory and inhibitory neurons, each with specific electrophysiological and biochemical properties, synaptic connections, and in vivo functions, but their basic functional and anatomical organization from cellular to network scale is poorly understood. Here we describe a method for the three-dimensional imaging of fluorescently-labeled neurons across large areas of the brain for the investigation of the cortical cellular organization. Specific types of neurons are labeled by the injection of fluorescent retrograde neuronal tracers or expression of fluorescent proteins in transgenic mice. Block brain samples, e.g., a hemisphere, are prepared after fixation, made transparent with tissue clearing methods, and subjected to fluorescent immunolabeling of the specific cell types. Large areas are scanned using confocal or two-photon microscopes equipped with large working distance objectives and motorized stages. This method can resolve the periodic organization of the cell type-specific microcolumn functional modules in the mouse neocortex. The procedure can be useful for the study of three-dimensional cellular architecture in the diverse brain areas and other complex tissues." @default.
• W2891449152 created "2018-09-27" @default.
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• W2891449152 date "2018-09-05" @default.
• W2891449152 modified "2023-09-25" @default.
• W2891449152 title "Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex" @default.
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• W2891449152 doi "https://doi.org/10.3791/58027" @default.
• W2891449152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6235110" @default.
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• W2891449152 hasPublicationYear "2018" @default.
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