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• W2891449544 abstract "Summary Vaccines can serve as essential tools to prevent bacterial diseases via the induction of long‐lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and Fc‐gamma receptors (Fc γ Rs) can potentially play a crucial role in IgG‐mediated immunity against bacterial diseases. However, their relative importance in vivo is unclear, and has been the object of controversy and debate. In this brief study, we have used gene‐targeted mice lacking either Fc γ RI , II , II and IV or the C3 complement component as well as a novel mouse strain lacking both C3 and Fc γ Rs to conclusively show the essential role of complement in antibody‐mediated host resistance to Salmonella enterica systemic infection. By comparing the effect of IgG2a antibodies against Salmonella O‐antigen in gene‐targeted mice, we demonstrate that the complement system is essential for the IgG‐mediated reduction of bacterial numbers in the tissues." @default.
• W2891449544 created "2018-09-27" @default.
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• W2891449544 date "2018-10-10" @default.
• W2891449544 modified "2023-10-05" @default.
• W2891449544 title "The essential role of complement in antibody-mediated resistance to<i>Salmonella</i>" @default.
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• W2891449544 doi "https://doi.org/10.1111/imm.13000" @default.
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