Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891457887> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2891457887 abstract "Compromised perfusion due to ligation of arteries and veins in esophagectomy with gastric tube reconstruction often (5-20%) results in necrosis and anastomotic leakage, which relate to high morbidity and mortality (3-4%). Ephedrine is used widely in anesthesia to treat intraoperative hypotension and may improve perfusion by the increase of cardiac output and mean arterial pressure (MAP). This study tests the effect of ephedrine on perfusion of the future anastomotic site of the gastric conduit, measured by laser speckle contrast imaging (LSCI). This prospective, observational, in vivo pilot study includes 26 patients undergoing esophagectomy with gastric tube reconstruction from October 2015 to June 2016 in the Academic Medical Center (Amsterdam). Perfusion of the gastric conduit was measured with LSCI directly after reconstruction and after an increase of MAP by ephedrine 5 mg. Perfusion was quantified in flux (laser speckle perfusion units, LSPU) in four perfusion locations, from good perfusion (base of the gastric tube) toward decreased perfusion (fundus). Intrapatient differences before and after ephedrine in terms flux were statistically tested for significance with a paired t-test. LSCI was feasible to image gastric microcirculation in all patients. Flux (LSPU) was significantly higher in the base of the gastric tube (791 ± 442) compared to the fundus (328 ± 187) (P < 0.001). After administration of ephedrine, flux increased significantly in the fundus (P < 0.05) measured intrapatients. Three patients developed anastomotic leakage. In these patients, the difference between measured flux in the fundus compared to the base of the gastric tube was high. This study presents the effect of ephedrine on perfusion of the gastric tissue measured with LSCI in terms of flux (LSPU) after esophagectomy with gastric tube reconstruction. We show a small but significant difference between flux measured before and after administration of ephedrine in the future anastomotic tissue (313 ± 178 vs. 397 ± 290). We also show a significant decrease of flux toward the fundus." @default.
- W2891457887 created "2018-09-27" @default.
- W2891457887 creator A5000174840 @default.
- W2891457887 creator A5011373751 @default.
- W2891457887 creator A5015997023 @default.
- W2891457887 creator A5016495434 @default.
- W2891457887 creator A5034139490 @default.
- W2891457887 creator A5042314770 @default.
- W2891457887 creator A5056403081 @default.
- W2891457887 creator A5064553394 @default.
- W2891457887 date "2018-04-13" @default.
- W2891457887 modified "2023-09-23" @default.
- W2891457887 title "Effect of ephedrine on gastric conduit perfusion measured by laser speckle contrast imaging after esophagectomy: a prospective in vivo cohort study" @default.
- W2891457887 cites W1507205421 @default.
- W2891457887 cites W1578884491 @default.
- W2891457887 cites W1601369164 @default.
- W2891457887 cites W1805859377 @default.
- W2891457887 cites W1989291415 @default.
- W2891457887 cites W1997582745 @default.
- W2891457887 cites W1997644803 @default.
- W2891457887 cites W1999959441 @default.
- W2891457887 cites W2001641740 @default.
- W2891457887 cites W2017345554 @default.
- W2891457887 cites W2022606810 @default.
- W2891457887 cites W2026881105 @default.
- W2891457887 cites W2039502231 @default.
- W2891457887 cites W2042767852 @default.
- W2891457887 cites W2075234645 @default.
- W2891457887 cites W2097459899 @default.
- W2891457887 cites W2120330172 @default.
- W2891457887 cites W2147829586 @default.
- W2891457887 cites W2150089164 @default.
- W2891457887 cites W2154444715 @default.
- W2891457887 cites W2157222645 @default.
- W2891457887 cites W2329002931 @default.
- W2891457887 cites W2342459904 @default.
- W2891457887 cites W2464343334 @default.
- W2891457887 cites W2746920496 @default.
- W2891457887 cites W4296024375 @default.
- W2891457887 doi "https://doi.org/10.1093/dote/doy031" @default.
- W2891457887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29668909" @default.
- W2891457887 hasPublicationYear "2018" @default.
- W2891457887 type Work @default.
- W2891457887 sameAs 2891457887 @default.
- W2891457887 citedByCount "7" @default.
- W2891457887 countsByYear W28914578872018 @default.
- W2891457887 countsByYear W28914578872019 @default.
- W2891457887 countsByYear W28914578872020 @default.
- W2891457887 countsByYear W28914578872021 @default.
- W2891457887 crossrefType "journal-article" @default.
- W2891457887 hasAuthorship W2891457887A5000174840 @default.
- W2891457887 hasAuthorship W2891457887A5011373751 @default.
- W2891457887 hasAuthorship W2891457887A5015997023 @default.
- W2891457887 hasAuthorship W2891457887A5016495434 @default.
- W2891457887 hasAuthorship W2891457887A5034139490 @default.
- W2891457887 hasAuthorship W2891457887A5042314770 @default.
- W2891457887 hasAuthorship W2891457887A5056403081 @default.
- W2891457887 hasAuthorship W2891457887A5064553394 @default.
- W2891457887 hasConcept C102290492 @default.
- W2891457887 hasConcept C126838900 @default.
- W2891457887 hasConcept C135691158 @default.
- W2891457887 hasConcept C141071460 @default.
- W2891457887 hasConcept C146957229 @default.
- W2891457887 hasConcept C154945302 @default.
- W2891457887 hasConcept C2989005 @default.
- W2891457887 hasConcept C41008148 @default.
- W2891457887 hasConcept C42219234 @default.
- W2891457887 hasConcept C71924100 @default.
- W2891457887 hasConcept C8443397 @default.
- W2891457887 hasConceptScore W2891457887C102290492 @default.
- W2891457887 hasConceptScore W2891457887C126838900 @default.
- W2891457887 hasConceptScore W2891457887C135691158 @default.
- W2891457887 hasConceptScore W2891457887C141071460 @default.
- W2891457887 hasConceptScore W2891457887C146957229 @default.
- W2891457887 hasConceptScore W2891457887C154945302 @default.
- W2891457887 hasConceptScore W2891457887C2989005 @default.
- W2891457887 hasConceptScore W2891457887C41008148 @default.
- W2891457887 hasConceptScore W2891457887C42219234 @default.
- W2891457887 hasConceptScore W2891457887C71924100 @default.
- W2891457887 hasConceptScore W2891457887C8443397 @default.
- W2891457887 hasIssue "10" @default.
- W2891457887 hasLocation W28914578871 @default.
- W2891457887 hasLocation W28914578872 @default.
- W2891457887 hasOpenAccess W2891457887 @default.
- W2891457887 hasPrimaryLocation W28914578871 @default.
- W2891457887 hasRelatedWork W104630177 @default.
- W2891457887 hasRelatedWork W2024932886 @default.
- W2891457887 hasRelatedWork W2356249032 @default.
- W2891457887 hasRelatedWork W2366627568 @default.
- W2891457887 hasRelatedWork W2382350448 @default.
- W2891457887 hasRelatedWork W2911918686 @default.
- W2891457887 hasRelatedWork W2958773234 @default.
- W2891457887 hasRelatedWork W3032311490 @default.
- W2891457887 hasRelatedWork W3185300475 @default.
- W2891457887 hasRelatedWork W3207490395 @default.
- W2891457887 hasVolume "31" @default.
- W2891457887 isParatext "false" @default.
- W2891457887 isRetracted "false" @default.
- W2891457887 magId "2891457887" @default.
- W2891457887 workType "article" @default.