Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891459934> ?p ?o ?g. }
- W2891459934 endingPage "37.e5" @default.
- W2891459934 startingPage "21" @default.
- W2891459934 abstract "How embryonic progenitors coordinate cell fate specification and establish transcriptional and signaling competence is a fundamental question in developmental biology. Here, we show that transcription factor ΔNp63 profoundly changes the transcriptome and remodels thousands of open chromatin regions of Krt8+ progenitors during epidermal fate specification. ATAC-seq and single-cell RNA-seq reveal that ΔNp63-dependent programs govern epidermal lineage formation, and ΔNp63-independent programs, mediated by AP2 and AP1 transcription factors, promote epidermal differentiation and epithelial-to-mesenchymal transition. ΔNp63 promotes Wnt signaling by directly upregulating Wnt ligands, Frizzled receptors, and transcription factors. Deletion of β-catenin in Krt8+ progenitors delays their maturation into Krt5+ progenitors. The lack of epidermal Wnt production in the absence of ΔNp63 also incapacitates Wnt activation in the underlying dermal cells. These findings reveal the remarkable changes of the transcriptome, open chromatin, and signaling pathways at the onset of skin development and uncover the molecular cascade for epidermal lineage formation." @default.
- W2891459934 created "2018-09-27" @default.
- W2891459934 creator A5008710997 @default.
- W2891459934 creator A5025090427 @default.
- W2891459934 creator A5027026155 @default.
- W2891459934 creator A5041020628 @default.
- W2891459934 creator A5042149318 @default.
- W2891459934 creator A5062131772 @default.
- W2891459934 creator A5091477523 @default.
- W2891459934 date "2018-10-01" @default.
- W2891459934 modified "2023-10-18" @default.
- W2891459934 title "Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin" @default.
- W2891459934 cites W1482923899 @default.
- W2891459934 cites W1513329088 @default.
- W2891459934 cites W1828641238 @default.
- W2891459934 cites W1850260711 @default.
- W2891459934 cites W1964951991 @default.
- W2891459934 cites W1977436879 @default.
- W2891459934 cites W1979814807 @default.
- W2891459934 cites W1986285972 @default.
- W2891459934 cites W1990768206 @default.
- W2891459934 cites W1997774826 @default.
- W2891459934 cites W1998069891 @default.
- W2891459934 cites W2006773272 @default.
- W2891459934 cites W2007232912 @default.
- W2891459934 cites W2010807493 @default.
- W2891459934 cites W2011842366 @default.
- W2891459934 cites W2014677321 @default.
- W2891459934 cites W2021341670 @default.
- W2891459934 cites W2024957578 @default.
- W2891459934 cites W2031822272 @default.
- W2891459934 cites W2053139101 @default.
- W2891459934 cites W2054052732 @default.
- W2891459934 cites W2058746018 @default.
- W2891459934 cites W2060823106 @default.
- W2891459934 cites W2061008214 @default.
- W2891459934 cites W2062336866 @default.
- W2891459934 cites W2072420580 @default.
- W2891459934 cites W2077505721 @default.
- W2891459934 cites W2078449413 @default.
- W2891459934 cites W2082161467 @default.
- W2891459934 cites W2084385289 @default.
- W2891459934 cites W2084686942 @default.
- W2891459934 cites W2086376086 @default.
- W2891459934 cites W2091643574 @default.
- W2891459934 cites W2091776694 @default.
- W2891459934 cites W2101139097 @default.
- W2891459934 cites W2102619694 @default.
- W2891459934 cites W2107474918 @default.
- W2891459934 cites W2111334492 @default.
- W2891459934 cites W2113645544 @default.
- W2891459934 cites W2114104545 @default.
- W2891459934 cites W2117757143 @default.
- W2891459934 cites W2122109009 @default.
- W2891459934 cites W2125987139 @default.
- W2891459934 cites W2126925922 @default.
- W2891459934 cites W2130410032 @default.
- W2891459934 cites W2134526812 @default.
- W2891459934 cites W2135200683 @default.
- W2891459934 cites W2140729960 @default.
- W2891459934 cites W2146749615 @default.
- W2891459934 cites W2154307309 @default.
- W2891459934 cites W2166724005 @default.
- W2891459934 cites W2167380395 @default.
- W2891459934 cites W2170551349 @default.
- W2891459934 cites W2171092698 @default.
- W2891459934 cites W2171808845 @default.
- W2891459934 cites W2179438025 @default.
- W2891459934 cites W2216103240 @default.
- W2891459934 cites W2266703738 @default.
- W2891459934 cites W2551820454 @default.
- W2891459934 cites W2555109040 @default.
- W2891459934 cites W2564889673 @default.
- W2891459934 cites W2794480084 @default.
- W2891459934 cites W2951506174 @default.
- W2891459934 cites W4230752345 @default.
- W2891459934 doi "https://doi.org/10.1016/j.devcel.2018.08.010" @default.
- W2891459934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6177292" @default.
- W2891459934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300587" @default.
- W2891459934 hasPublicationYear "2018" @default.
- W2891459934 type Work @default.
- W2891459934 sameAs 2891459934 @default.
- W2891459934 citedByCount "57" @default.
- W2891459934 countsByYear W28914599342018 @default.
- W2891459934 countsByYear W28914599342019 @default.
- W2891459934 countsByYear W28914599342020 @default.
- W2891459934 countsByYear W28914599342021 @default.
- W2891459934 countsByYear W28914599342022 @default.
- W2891459934 countsByYear W28914599342023 @default.
- W2891459934 crossrefType "journal-article" @default.
- W2891459934 hasAuthorship W2891459934A5008710997 @default.
- W2891459934 hasAuthorship W2891459934A5025090427 @default.
- W2891459934 hasAuthorship W2891459934A5027026155 @default.
- W2891459934 hasAuthorship W2891459934A5041020628 @default.
- W2891459934 hasAuthorship W2891459934A5042149318 @default.
- W2891459934 hasAuthorship W2891459934A5062131772 @default.
- W2891459934 hasAuthorship W2891459934A5091477523 @default.
- W2891459934 hasBestOaLocation W28914599341 @default.