FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891462488> ?p ?o ?g. }

• W2891462488 endingPage "766" @default.
• W2891462488 startingPage "751" @default.
• W2891462488 abstract "Abstract Background Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mendelian Randomization (MR) and mediation analyses. Methods We developed a novel genetic instrument for TL in chromosome 5p15.33, using variants identified through deep-sequencing, that were genotyped in 2051 cancer-free subjects. Next, we conducted an MR analysis of lung (16 396 cases, 13 013 controls) and head and neck cancer (4415 cases, 5013 controls) using eight genetic instruments for TL. Lastly, the 5p15.33 instrument and distinct 5p15.33 lung cancer risk loci were evaluated using two-sample mediation analysis, to quantify their direct and indirect, telomere-mediated, effects. Results The multi-allelic 5p15.33 instrument explained 1.49–2.00% of TL variation in our data (p = 2.6 × 10–9). The MR analysis estimated that a 1000 base-pair increase in TL increases risk of lung cancer [odds ratio (OR) = 1.41, 95% confidence interval (CI): 1.20–1.65] and lung adenocarcinoma (OR = 1.92, 95% CI: 1.51–2.22), but not squamous lung carcinoma (OR = 1.04, 95% CI: 0.83–1.29) or head and neck cancers (OR = 0.90, 95% CI: 0.70–1.05). Mediation analysis of the 5p15.33 instrument indicated an absence of direct effects on lung cancer risk (OR = 1.00, 95% CI: 0.95–1.04). Analysis of distinct 5p15.33 susceptibility variants estimated that TL mediates up to 40% of the observed associations with lung cancer risk. Conclusions Our findings support a causal role for long telomeres in lung cancer aetiology, particularly for adenocarcinoma, and demonstrate that telomere maintenance partially mediates the lung cancer susceptibility conferred by 5p15.33 loci." @default.
• W2891462488 created "2018-09-27" @default.
• W2891462488 creator A5000350877 @default.
• W2891462488 creator A5000702560 @default.
• W2891462488 creator A5000739842 @default.
• W2891462488 creator A5000877350 @default.
• W2891462488 creator A5001258652 @default.
• W2891462488 creator A5001857260 @default.
• W2891462488 creator A5002292616 @default.
• W2891462488 creator A5002463978 @default.
• W2891462488 creator A5002857362 @default.
• W2891462488 creator A5005876352 @default.
• W2891462488 creator A5009454568 @default.
• W2891462488 creator A5011954023 @default.
• W2891462488 creator A5013184354 @default.
• W2891462488 creator A5015685053 @default.
• W2891462488 creator A5017074857 @default.
• W2891462488 creator A5017309816 @default.
• W2891462488 creator A5017818032 @default.
• W2891462488 creator A5019329822 @default.
• W2891462488 creator A5019717619 @default.
• W2891462488 creator A5023531951 @default.
• W2891462488 creator A5024663234 @default.
• W2891462488 creator A5024933419 @default.
• W2891462488 creator A5027129558 @default.
• W2891462488 creator A5027838123 @default.
• W2891462488 creator A5027863885 @default.
• W2891462488 creator A5028047746 @default.
• W2891462488 creator A5028712491 @default.
• W2891462488 creator A5028989565 @default.
• W2891462488 creator A5029703491 @default.
• W2891462488 creator A5030064179 @default.
• W2891462488 creator A5031525169 @default.
• W2891462488 creator A5032460782 @default.
• W2891462488 creator A5033421883 @default.
• W2891462488 creator A5033972061 @default.
• W2891462488 creator A5034359692 @default.
• W2891462488 creator A5034598130 @default.
• W2891462488 creator A5037498104 @default.
• W2891462488 creator A5037549775 @default.
• W2891462488 creator A5037728205 @default.
• W2891462488 creator A5040950914 @default.
• W2891462488 creator A5043336940 @default.
• W2891462488 creator A5045259667 @default.
• W2891462488 creator A5045763456 @default.
• W2891462488 creator A5046671345 @default.
• W2891462488 creator A5048880494 @default.
• W2891462488 creator A5053074659 @default.
• W2891462488 creator A5053712654 @default.
• W2891462488 creator A5053915331 @default.
• W2891462488 creator A5055939964 @default.
• W2891462488 creator A5055941002 @default.
• W2891462488 creator A5057649971 @default.
• W2891462488 creator A5058962034 @default.
• W2891462488 creator A5060049615 @default.
• W2891462488 creator A5066518394 @default.
• W2891462488 creator A5066835564 @default.
• W2891462488 creator A5066957198 @default.
• W2891462488 creator A5069531414 @default.
• W2891462488 creator A5071248262 @default.
• W2891462488 creator A5071983898 @default.
• W2891462488 creator A5073656376 @default.
• W2891462488 creator A5073925695 @default.
• W2891462488 creator A5074808099 @default.
• W2891462488 creator A5075544315 @default.
• W2891462488 creator A5081350789 @default.
• W2891462488 creator A5082304021 @default.
• W2891462488 creator A5085715708 @default.
• W2891462488 creator A5087836097 @default.
• W2891462488 creator A5088224394 @default.
• W2891462488 creator A5089473534 @default.
• W2891462488 creator A5090043723 @default.
• W2891462488 date "2018-07-28" @default.
• W2891462488 modified "2023-10-18" @default.
• W2891462488 title "Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers" @default.
• W2891462488 cites W1541877559 @default.
• W2891462488 cites W1756179744 @default.
• W2891462488 cites W1905058580 @default.
• W2891462488 cites W1967978928 @default.
• W2891462488 cites W1972907064 @default.
• W2891462488 cites W1975905059 @default.
• W2891462488 cites W1981132305 @default.
• W2891462488 cites W2003905926 @default.
• W2891462488 cites W2004352690 @default.
• W2891462488 cites W2005441291 @default.
• W2891462488 cites W2005908883 @default.
• W2891462488 cites W2005996436 @default.
• W2891462488 cites W2007846880 @default.
• W2891462488 cites W2009846643 @default.
• W2891462488 cites W2014324433 @default.
• W2891462488 cites W2021708309 @default.
• W2891462488 cites W2023245620 @default.
• W2891462488 cites W2024809912 @default.
• W2891462488 cites W2026197918 @default.
• W2891462488 cites W2030976397 @default.
• W2891462488 cites W2031230149 @default.
• W2891462488 cites W2031852598 @default.
• W2891462488 cites W2037762348 @default.

• next