Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891463164> ?p ?o ?g. }
- W2891463164 endingPage "1868" @default.
- W2891463164 startingPage "1859" @default.
- W2891463164 abstract "Abstract Background The transcriptional coactivator peroxisome proliferator-activated receptor- γ coactivator (PGC-1 α ), termed the ‘master regulator of mitochondrial biogenesis’, has been implicated in stress and resilience to stress-induced depressive-like behaviours in animal models. However, there has been no study conducted to date to examine PGC-1 α levels in patients with depression or in response to antidepressant treatment. Our aim was to assess PGC-1α mRNA levels in blood from healthy controls and patients with depression pre-/post-electroconvulsive therapy (ECT), and to examine the relationship between blood PGC-1α mRNA levels and clinical symptoms and outcomes with ECT. Methods Whole blood PGC-1α mRNA levels were analysed in samples from 67 patients with a major depressive episode and 70 healthy controls, and in patient samples following a course of ECT using quantitative real-time polymerase chain reaction (qRT-PCR). Exploratory subgroup correlational analyses were carried out to determine the relationship between PGC-1α and mood scores. Results PGC-1α levels were lower in patients with depression compared with healthy controls ( p = 0.03). This lower level was predominantly accounted for by patients with psychotic unipolar depression ( p = 0.004). ECT did not alter PGC-1α levels in the depressed group as a whole, though exploratory analyses revealed a significant increase in PGC-1α in patients with psychotic unipolar depression post-ECT ( p = 0.045). We found no relationship between PGC-1α mRNA levels and depression severity or the clinical response to ECT. Conclusions PGC-1 α may represent a novel therapeutic target for the treatment of depression, and be a common link between various pathophysiological processes implicated in depression." @default.
- W2891463164 created "2018-09-27" @default.
- W2891463164 creator A5044093658 @default.
- W2891463164 creator A5046051362 @default.
- W2891463164 creator A5055195696 @default.
- W2891463164 date "2018-09-07" @default.
- W2891463164 modified "2023-10-10" @default.
- W2891463164 title "Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy" @default.
- W2891463164 cites W1481607792 @default.
- W2891463164 cites W1583767403 @default.
- W2891463164 cites W1752063994 @default.
- W2891463164 cites W1780685050 @default.
- W2891463164 cites W1827022404 @default.
- W2891463164 cites W1918135542 @default.
- W2891463164 cites W1966030580 @default.
- W2891463164 cites W1975487923 @default.
- W2891463164 cites W1976302347 @default.
- W2891463164 cites W1977822710 @default.
- W2891463164 cites W1978143106 @default.
- W2891463164 cites W1981219072 @default.
- W2891463164 cites W1982823302 @default.
- W2891463164 cites W1985438873 @default.
- W2891463164 cites W1987699071 @default.
- W2891463164 cites W1990817194 @default.
- W2891463164 cites W1994161284 @default.
- W2891463164 cites W1996821192 @default.
- W2891463164 cites W1997008618 @default.
- W2891463164 cites W1998628114 @default.
- W2891463164 cites W2001566604 @default.
- W2891463164 cites W2002250647 @default.
- W2891463164 cites W2004148427 @default.
- W2891463164 cites W2008632158 @default.
- W2891463164 cites W2016344875 @default.
- W2891463164 cites W2018427433 @default.
- W2891463164 cites W2025937429 @default.
- W2891463164 cites W2032913694 @default.
- W2891463164 cites W2034630933 @default.
- W2891463164 cites W2038949549 @default.
- W2891463164 cites W2044782567 @default.
- W2891463164 cites W2062815987 @default.
- W2891463164 cites W2063583276 @default.
- W2891463164 cites W2065408367 @default.
- W2891463164 cites W2069602531 @default.
- W2891463164 cites W2075098213 @default.
- W2891463164 cites W2080048804 @default.
- W2891463164 cites W2083456009 @default.
- W2891463164 cites W2097987102 @default.
- W2891463164 cites W2103661055 @default.
- W2891463164 cites W2105404724 @default.
- W2891463164 cites W2107277218 @default.
- W2891463164 cites W2107676676 @default.
- W2891463164 cites W2111116481 @default.
- W2891463164 cites W2117415152 @default.
- W2891463164 cites W2118187920 @default.
- W2891463164 cites W2120246991 @default.
- W2891463164 cites W2123106337 @default.
- W2891463164 cites W2127624653 @default.
- W2891463164 cites W2128452653 @default.
- W2891463164 cites W2136153483 @default.
- W2891463164 cites W2137500360 @default.
- W2891463164 cites W2137811546 @default.
- W2891463164 cites W2140399354 @default.
- W2891463164 cites W2141789735 @default.
- W2891463164 cites W2143527146 @default.
- W2891463164 cites W2145866317 @default.
- W2891463164 cites W2146090441 @default.
- W2891463164 cites W2152101492 @default.
- W2891463164 cites W2153108053 @default.
- W2891463164 cites W2153393568 @default.
- W2891463164 cites W2171736442 @default.
- W2891463164 cites W2182104458 @default.
- W2891463164 cites W2199203598 @default.
- W2891463164 cites W2287350600 @default.
- W2891463164 cites W2291729359 @default.
- W2891463164 cites W2414467028 @default.
- W2891463164 cites W2472459469 @default.
- W2891463164 cites W2525298249 @default.
- W2891463164 cites W2549722103 @default.
- W2891463164 cites W2600069286 @default.
- W2891463164 cites W2763351098 @default.
- W2891463164 cites W2766457937 @default.
- W2891463164 cites W2782634046 @default.
- W2891463164 cites W2794645689 @default.
- W2891463164 cites W4292528167 @default.
- W2891463164 doi "https://doi.org/10.1017/s0033291718002556" @default.
- W2891463164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30191781" @default.
- W2891463164 hasPublicationYear "2018" @default.
- W2891463164 type Work @default.
- W2891463164 sameAs 2891463164 @default.
- W2891463164 citedByCount "13" @default.
- W2891463164 countsByYear W28914631642020 @default.
- W2891463164 countsByYear W28914631642021 @default.
- W2891463164 countsByYear W28914631642022 @default.
- W2891463164 countsByYear W28914631642023 @default.
- W2891463164 crossrefType "journal-article" @default.
- W2891463164 hasAuthorship W2891463164A5044093658 @default.
- W2891463164 hasAuthorship W2891463164A5046051362 @default.
- W2891463164 hasAuthorship W2891463164A5055195696 @default.