FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891465305> ?p ?o ?g. }

• W2891465305 endingPage "1639" @default.
• W2891465305 startingPage "1631" @default.
• W2891465305 abstract "Activated T helper type 2 (Th2) cells are believed to play a pivotal role in allergic airway inflammation, but which cells attract and activate Th2 cells locally have not been fully determined. Recently, it was shown in an experimental human model of allergic rhinitis (AR) that activated monocytes rapidly accumulate in the nasal mucosa after local allergen challenge, where they promote recruitment of Th2 cells and eosinophils.To investigate whether monocytes are recruited to the lungs in paediatric asthma.Tissue samples obtained from children and adolescents with fatal asthma attack (n = 12), age-matched non-atopic controls (n = 9) and allergen-challenged AR patients (n = 8) were subjected to in situ immunostaining.Monocytes, identified as CD68+S100A8/A9+ cells, were significantly increased in the lower airway mucosa and in the alveoli of fatal asthma patients compared with control individuals. Interestingly, cellular aggregates containing CD68+S100A8/A9+ monocytes obstructing the lumen of bronchioles were found in asthmatics (8 out of 12) but not in controls. Analysing tissue specimens from challenged AR patients, we confirmed that co-staining with CD68 and S100A8/A9 was a valid method to identify recently recruited monocytes. We also showed that the vast majority of accumulating monocytes both in the lungs and in the nasal mucosa expressed matrix metalloproteinase 10, suggesting that this protein may be involved in their migration within the tissue.Monocytes accumulated in the lungs of children and adolescents with fatal asthma attack. This finding strongly suggests that monocytes are directly involved in the immunopathology of asthma and that these pro-inflammatory cells are potential targets for therapy." @default.
• W2891465305 created "2018-09-27" @default.
• W2891465305 creator A5010277614 @default.
• W2891465305 creator A5018035188 @default.
• W2891465305 creator A5018231357 @default.
• W2891465305 creator A5052605298 @default.
• W2891465305 creator A5053715606 @default.
• W2891465305 creator A5064942404 @default.
• W2891465305 creator A5075043458 @default.
• W2891465305 creator A5077865830 @default.
• W2891465305 creator A5080996618 @default.
• W2891465305 creator A5081680922 @default.
• W2891465305 creator A5086841100 @default.
• W2891465305 date "2018-10-16" @default.
• W2891465305 modified "2023-10-18" @default.
• W2891465305 title "Monocytes accumulate in the airways of children with fatal asthma" @default.
• W2891465305 cites W1525354362 @default.
• W2891465305 cites W1563070305 @default.
• W2891465305 cites W1988348542 @default.
• W2891465305 cites W1990861126 @default.
• W2891465305 cites W2015298622 @default.
• W2891465305 cites W2025134962 @default.
• W2891465305 cites W2036788491 @default.
• W2891465305 cites W2040250341 @default.
• W2891465305 cites W2041189421 @default.
• W2891465305 cites W2044789422 @default.
• W2891465305 cites W2050455029 @default.
• W2891465305 cites W2051049597 @default.
• W2891465305 cites W2062207460 @default.
• W2891465305 cites W2069891658 @default.
• W2891465305 cites W2096210343 @default.
• W2891465305 cites W2099289777 @default.
• W2891465305 cites W2099938481 @default.
• W2891465305 cites W2103153413 @default.
• W2891465305 cites W2103868159 @default.
• W2891465305 cites W2104299175 @default.
• W2891465305 cites W2111263764 @default.
• W2891465305 cites W2117891493 @default.
• W2891465305 cites W2139213443 @default.
• W2891465305 cites W2150781849 @default.
• W2891465305 cites W2150872976 @default.
• W2891465305 cites W2153272081 @default.
• W2891465305 cites W2272591899 @default.
• W2891465305 cites W2396665399 @default.
• W2891465305 cites W2422818699 @default.
• W2891465305 cites W2466541569 @default.
• W2891465305 cites W2614424729 @default.
• W2891465305 cites W2742514069 @default.
• W2891465305 cites W2778450829 @default.
• W2891465305 cites W2786658869 @default.
• W2891465305 doi "https://doi.org/10.1111/cea.13265" @default.
• W2891465305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30184280" @default.
• W2891465305 hasPublicationYear "2018" @default.
• W2891465305 type Work @default.
• W2891465305 sameAs 2891465305 @default.
• W2891465305 citedByCount "30" @default.
• W2891465305 countsByYear W28914653052019 @default.
• W2891465305 countsByYear W28914653052020 @default.
• W2891465305 countsByYear W28914653052021 @default.
• W2891465305 countsByYear W28914653052022 @default.
• W2891465305 countsByYear W28914653052023 @default.
• W2891465305 crossrefType "journal-article" @default.
• W2891465305 hasAuthorship W2891465305A5010277614 @default.
• W2891465305 hasAuthorship W2891465305A5018035188 @default.
• W2891465305 hasAuthorship W2891465305A5018231357 @default.
• W2891465305 hasAuthorship W2891465305A5052605298 @default.
• W2891465305 hasAuthorship W2891465305A5053715606 @default.
• W2891465305 hasAuthorship W2891465305A5064942404 @default.
• W2891465305 hasAuthorship W2891465305A5075043458 @default.
• W2891465305 hasAuthorship W2891465305A5077865830 @default.
• W2891465305 hasAuthorship W2891465305A5080996618 @default.
• W2891465305 hasAuthorship W2891465305A5081680922 @default.
• W2891465305 hasAuthorship W2891465305A5086841100 @default.
• W2891465305 hasBestOaLocation W28914653052 @default.
• W2891465305 hasConcept C142724271 @default.
• W2891465305 hasConcept C203014093 @default.
• W2891465305 hasConcept C204232928 @default.
• W2891465305 hasConcept C207480886 @default.
• W2891465305 hasConcept C2776042228 @default.
• W2891465305 hasConcept C2776460901 @default.
• W2891465305 hasConcept C2776914184 @default.
• W2891465305 hasConcept C2777037409 @default.
• W2891465305 hasConcept C2777716647 @default.
• W2891465305 hasConcept C2780510475 @default.
• W2891465305 hasConcept C4224716 @default.
• W2891465305 hasConcept C71924100 @default.
• W2891465305 hasConceptScore W2891465305C142724271 @default.
• W2891465305 hasConceptScore W2891465305C203014093 @default.
• W2891465305 hasConceptScore W2891465305C204232928 @default.
• W2891465305 hasConceptScore W2891465305C207480886 @default.
• W2891465305 hasConceptScore W2891465305C2776042228 @default.
• W2891465305 hasConceptScore W2891465305C2776460901 @default.
• W2891465305 hasConceptScore W2891465305C2776914184 @default.
• W2891465305 hasConceptScore W2891465305C2777037409 @default.
• W2891465305 hasConceptScore W2891465305C2777716647 @default.
• W2891465305 hasConceptScore W2891465305C2780510475 @default.
• W2891465305 hasConceptScore W2891465305C4224716 @default.
• W2891465305 hasConceptScore W2891465305C71924100 @default.

• next