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• W2891465477 abstract "Candidiasis is the most common fungal infection in immunocompromised patients, and Candida albicans is the fourth leading agent of nosocomial infections. Mortality from this infection is significant; however, the therapeutic treatment is limited, which demands the search for new drugs and new targets. In this context, oxidosqualene cyclase (OSC) catalyzes the cyclization of the 2,3-oxidosqualene to form lanosterol, an intermediate of ergosterol biosynthesis. Therefore, this enzyme constitutes an attractive therapeutic target. Thus, the aim of this study is to identify potential inhibitors of C. albicans OSC (CaOSC) from a marketed drugs database in order to discover new antifungal agents. The CaOSC 3D model was constructed using the Swiss-Model server and important features for CaOSC inhibition were identified by molecular docking of known inhibitors using Autodock Vina 1.1.2. Subsequently, virtual screening helped to identify calcitriol, the active form of vitamin D, and other four drugs, as potential inhibitors of CaOSC. The selected drugs presented an interesting pattern of interactions with this enzyme, including hydrogen bond with Asp450, a key residue in the active site. Thus, the antifungal activity of calcitriol was evaluated in vitro against Candida spp strains. Calcitriol showed antifungal activity against C. albicans and C. tropicalis, which reinforces the potential of this compound as candidate of CaOSC inhibitor. In short, the present study provides important insights for the development of new oxidosqualene cyclase inhibitors as antifungals." @default.
• W2891465477 created "2018-09-27" @default.
• W2891465477 creator A5014798212 @default.
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• W2891465477 creator A5064027549 @default.
• W2891465477 creator A5080200331 @default.
• W2891465477 date "2019-01-01" @default.
• W2891465477 modified "2023-10-16" @default.
• W2891465477 title "Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase" @default.
• W2891465477 cites W1887624773 @default.
• W2891465477 cites W1948251094 @default.
• W2891465477 cites W1970771565 @default.
• W2891465477 cites W1972948135 @default.
• W2891465477 cites W1984308741 @default.
• W2891465477 cites W1986191025 @default.
• W2891465477 cites W1988284704 @default.
• W2891465477 cites W1992192767 @default.
• W2891465477 cites W2005611806 @default.
• W2891465477 cites W2010659155 @default.
• W2891465477 cites W2015642465 @default.
• W2891465477 cites W2016155858 @default.
• W2891465477 cites W2027264226 @default.
• W2891465477 cites W2027870803 @default.
• W2891465477 cites W2030651626 @default.
• W2891465477 cites W2031264029 @default.
• W2891465477 cites W2031271408 @default.
• W2891465477 cites W2031491721 @default.
• W2891465477 cites W2038668045 @default.
• W2891465477 cites W2044356100 @default.
• W2891465477 cites W2047041385 @default.
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• W2891465477 cites W2067975585 @default.
• W2891465477 cites W2068017935 @default.
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• W2891465477 cites W2071486470 @default.
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• W2891465477 doi "https://doi.org/10.1016/j.jsbmb.2018.09.001" @default.
• W2891465477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30193921" @default.
• W2891465477 hasPublicationYear "2019" @default.
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