Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891468310> ?p ?o ?g. }
- W2891468310 abstract "X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a replication sample of 3351 females, we show that genetic variation at three autosomal loci is associated with female-specific changes in X-chromosome methylation. Through cis-eQTL expression analysis, we map these loci to the genes SMCHD1/METTL4, TRIM6/HBG2, and ZSCAN9. Low-expression alleles of the loci are predominantly associated with mild hypomethylation of CpG islands near genes known to variably escape XCI, implicating the autosomal genes in variable XCI. Together, these results suggest a genetic basis for variable escape from XCI and highlight the potential of a population genomics approach to identify genes involved in XCI." @default.
- W2891468310 created "2018-09-27" @default.
- W2891468310 creator A5008602701 @default.
- W2891468310 creator A5011322150 @default.
- W2891468310 creator A5014572068 @default.
- W2891468310 creator A5017009749 @default.
- W2891468310 creator A5018092286 @default.
- W2891468310 creator A5018467489 @default.
- W2891468310 creator A5021033668 @default.
- W2891468310 creator A5023966597 @default.
- W2891468310 creator A5034668013 @default.
- W2891468310 creator A5035504682 @default.
- W2891468310 creator A5036197337 @default.
- W2891468310 creator A5041758867 @default.
- W2891468310 creator A5042511675 @default.
- W2891468310 creator A5049350976 @default.
- W2891468310 creator A5066260392 @default.
- W2891468310 creator A5067117138 @default.
- W2891468310 creator A5067900225 @default.
- W2891468310 creator A5069816083 @default.
- W2891468310 creator A5073064298 @default.
- W2891468310 creator A5073495611 @default.
- W2891468310 creator A5076106859 @default.
- W2891468310 creator A5078002980 @default.
- W2891468310 creator A5079752137 @default.
- W2891468310 creator A5082560822 @default.
- W2891468310 creator A5084500759 @default.
- W2891468310 creator A5084724064 @default.
- W2891468310 creator A5084999936 @default.
- W2891468310 creator A5090165102 @default.
- W2891468310 date "2018-09-14" @default.
- W2891468310 modified "2023-10-17" @default.
- W2891468310 title "Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation" @default.
- W2891468310 cites W1481885984 @default.
- W2891468310 cites W1512591645 @default.
- W2891468310 cites W1749851052 @default.
- W2891468310 cites W1975528145 @default.
- W2891468310 cites W1976816332 @default.
- W2891468310 cites W1979386638 @default.
- W2891468310 cites W1980991018 @default.
- W2891468310 cites W1992436001 @default.
- W2891468310 cites W2000580034 @default.
- W2891468310 cites W2015612792 @default.
- W2891468310 cites W2018380248 @default.
- W2891468310 cites W2018758172 @default.
- W2891468310 cites W2020958409 @default.
- W2891468310 cites W2029087061 @default.
- W2891468310 cites W2029146706 @default.
- W2891468310 cites W2032467048 @default.
- W2891468310 cites W2036897871 @default.
- W2891468310 cites W2041770101 @default.
- W2891468310 cites W2050161506 @default.
- W2891468310 cites W2058013228 @default.
- W2891468310 cites W2062598800 @default.
- W2891468310 cites W2066684435 @default.
- W2891468310 cites W2076154138 @default.
- W2891468310 cites W2080089210 @default.
- W2891468310 cites W2080215939 @default.
- W2891468310 cites W2090806216 @default.
- W2891468310 cites W2098380237 @default.
- W2891468310 cites W2098412979 @default.
- W2891468310 cites W2099107563 @default.
- W2891468310 cites W2101870168 @default.
- W2891468310 cites W2103419911 @default.
- W2891468310 cites W2103869399 @default.
- W2891468310 cites W2108088228 @default.
- W2891468310 cites W2109252993 @default.
- W2891468310 cites W2112946861 @default.
- W2891468310 cites W2116195449 @default.
- W2891468310 cites W2119514855 @default.
- W2891468310 cites W2124359985 @default.
- W2891468310 cites W2128016314 @default.
- W2891468310 cites W2129915465 @default.
- W2891468310 cites W2130135559 @default.
- W2891468310 cites W2132731072 @default.
- W2891468310 cites W2133305315 @default.
- W2891468310 cites W2135089294 @default.
- W2891468310 cites W2154849094 @default.
- W2891468310 cites W2157325134 @default.
- W2891468310 cites W2163667239 @default.
- W2891468310 cites W2165184227 @default.
- W2891468310 cites W2165556149 @default.
- W2891468310 cites W2166719147 @default.
- W2891468310 cites W2168300179 @default.
- W2891468310 cites W2168447003 @default.
- W2891468310 cites W2169456326 @default.
- W2891468310 cites W2170380265 @default.
- W2891468310 cites W2259938310 @default.
- W2891468310 cites W2284521682 @default.
- W2891468310 cites W2313190268 @default.
- W2891468310 cites W2316537321 @default.
- W2891468310 cites W2434565902 @default.
- W2891468310 cites W2510420694 @default.
- W2891468310 cites W2548300993 @default.
- W2891468310 cites W2553611287 @default.
- W2891468310 cites W2560048039 @default.
- W2891468310 cites W2611890902 @default.
- W2891468310 cites W2621892125 @default.
- W2891468310 cites W2766195635 @default.
- W2891468310 cites W2951674154 @default.