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• W2891468637 abstract "Metabolic syndrome and the risk of cholangiocarcinoma: a hospital-based case-control study in China Jianping Xiong,1,* Xin Lu,1,* Weiyu Xu,1,* Yi Bai,1 Hanchun Huang,1 Jin Bian,1 Lei Zhang,1 Junyu Long,1 Yiyao Xu,2 Zhenjie Wang,2 Haitao Zhao1 1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China; 2Health Screening Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China *These authors contributed equally to this work Background: Metabolic syndrome is regarded as a risk factor for hepatocellular carcinoma. However, no research has been conducted to investigate the association between metabolic syndrome and cholangiocarcinoma (CCA), especially in the Chinese population. Herein, a hospital-based case–control study was carried out in China to explore the association between metabolic syndrome and CCA risk. Patients and methods: In this study, 303 CCA patients (136 intrahepatic cholangiocarcinoma [ICC] and 167 extrahepatic cholangiocarcinoma [ECC]) were included, who were observed at Peking Union Medical College Hospital (PUMCH), from 2002 to 2014. Healthy controls were randomly selected from the database of PUMPH Health Screening Center. We retrospectively extracted metabolic syndrome and other possible risk factors from clinical records, followed by investigation of the relationship with CCA via calculation of ORs and 95% CIs using logistic regression analysis. Results: Metabolic syndrome was significantly and positively correlated with all CCA subtypes, with adjusted ORs (AORs) of 0.35 (95% CI =0.29–0.42) and 0.29 (95% CI =0.19–0.44) for ICC and ECC, respectively (both P" @default.
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• W2891468637 date "2018-09-01" @default.
• W2891468637 modified "2023-10-01" @default.
• W2891468637 title "Metabolic syndrome and the risk of cholangiocarcinoma: a hospital-based case&ndash;control study in China" @default.
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• W2891468637 doi "https://doi.org/10.2147/cmar.s175628" @default.
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