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- W2891469847 abstract "Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5-7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10-15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms-2. Larval zebrafish also exhibited decreased habituation to startle-inducing stimuli following noise exposure. The noise-induced sensitization was not due to changes in absolute hearing thresholds, but was specific to the auditory-evoked escape responses. The observed noise-induced sensitization was disrupted by AMPA receptor blockade using DNQX, but not NMDA receptor blockade. Together, these experiments suggest a complex effect of noise exposure on the neural circuits mediating auditory-evoked behaviors in larval zebrafish." @default.
- W2891469847 created "2018-09-27" @default.
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- W2891469847 date "2018-09-06" @default.
- W2891469847 modified "2023-10-14" @default.
- W2891469847 title "Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish" @default.
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- W2891469847 doi "https://doi.org/10.1007/s10162-018-00685-0" @default.
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