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• W2891469948 abstract "Six new (1–6) and nine known (7–15) staurosporine derivatives were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. NB-A13. The structures of the new staurosporine derivatives were established by extensive spectroscopic data interpretation. The absolute configurations of 1 and 2 were assigned by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. All of these compounds were screened for their cytotoxic activities against PC-3 and SW-620 cell lines. Compound 7 exhibited stronger inhibitory activity against SW-620 cell lines than the positive control staurosporine (25.10 nM), with IC50 values of 9.99 nM. Moreover, compounds 1–5, 8–13 and 15 also showed significant cytotoxicities with IC50 values ranging from 0.02 to 16.60 μM, while 6 exhibited no cytotoxic potency. Additionally, compounds 1–7 were also tested for enzyme inhibition activities of Protein kinase C theta (PKC-θ), and showed activity with IC50 values ranging from 0.06 to 9.43 μM except for compound 6, which has no inhibition activity." @default.
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• W2891469948 date "2019-02-01" @default.
• W2891469948 modified "2023-09-25" @default.
• W2891469948 title "Bioactive staurosporine derivatives from the Streptomyces sp. NB-A13" @default.
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• W2891469948 doi "https://doi.org/10.1016/j.bioorg.2018.09.016" @default.
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