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- W2891470992 abstract "Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson's disease Ulderico Freo, Maurizio Furnari, Carlo Ori Anesthesiology and Intensive Care Unit, Department of Medicine – DIMED, Padua University, Padua, Italy Background: Pain is a common and undertreated non-motor symptom in patients with Parkinson’s disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective: We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods: We retrospectively reviewed 21 PD patients treated with tapentadol extended release (ER) for chronic pain. Patients were evaluated before treatment and at 3 and 6 months during treatment for pain intensity (current, 24-hour average, and minimum and worst) with a 0–10 Numerical Rating Scale and the painDETECT questionnaire; for motor symptom severity with the Unified PD Rating Scale part III and the Hoehn and Yahr scale; for cognitive functions with Mini-Mental Status Examination, Corsi’s Block-Tapping test, Digit Span test, Digit-Symbol Substitution test, FAS test, Rey’s Auditory Verbal Learning test, Trail-Making test A and B and the 9-Hole Peg test; for anxiety and depression with the Hospital Anxiety and Depression Scale; and for the quality of life with the Short Form-12. Data were analyzed by 1-way analysis of variance and paired t-test, and by Friedman’s and Wilcoxon’s tests. Statistical significance was taken in all cases as P" @default.
- W2891470992 created "2018-09-27" @default.
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- W2891470992 date "2018-09-01" @default.
- W2891470992 modified "2023-09-25" @default.
- W2891470992 title "Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson’s disease" @default.
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- W2891470992 doi "https://doi.org/10.2147/jpr.s164939" @default.
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