FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891471308> ?p ?o ?g. }

• W2891471308 endingPage "380" @default.
• W2891471308 startingPage "365" @default.
• W2891471308 abstract "This study investigated bovine conceptus-induced modifications to the endometrial transcriptome related to effects of interferon tau (IFNT), conceptus origin (in vivo vs. in vitro), and conceptus sex. In vitro (IVF) or in vivo (superovulation and artificial insemination, AI) produced blastocysts were transferred into recipient heifers on day 7 of the estrous cycle. On day 15, IVF- or AI-derived conceptuses were obtained by uterine flushing and individually placed on endometrial explants in media for 6 h. Explants were also cultured with media alone as a control or media containing 100 ng/mL IFNT. Total explant RNA was analyzed by RNA-Seq. Incubation of endometrium with IFNT or IVF- or AI-derived conceptuses changed (P ≤ 0.001) expression of 491, 498, and 576 transcripts, respectively, compared to the control. Further, 369 differentially expressed genes (DEGs) were common between explants exposed to IFNT or a conceptus. A total of 240 DEGs were uniquely altered by conceptuses (IVF- and AI-derived) but not IFNT. Of these transcripts, 46 were shared between the IVF and AI groups, while 61 and 133 were specific to IVF and AI conceptuses, respectively. Five genes [melanophilin (MLPH), prominin-2 (PROM2), myeloid associated differentiation marker (MYADM), vomeronasal 1 receptor 4 like (VN1R4L) and 5-hydroxytryptamine receptor 1A (HTR1A)] were more abundant in endometrium exposed to female compared to male conceptuses (P < 0.001). A single gene [ADP-ribosylation factor like GTPase 4C (ARL4C)] was more abundant in response to male conceptuses (P < 0.001) than female conceptuses. These data support the hypothesis that conceptus regulation of gene expression in the endometrium is complex and involves factors other than IFNT that may have a biological role in pregnancy establishment." @default.
• W2891471308 created "2018-09-27" @default.
• W2891471308 creator A5001438788 @default.
• W2891471308 creator A5003493634 @default.
• W2891471308 creator A5023991491 @default.
• W2891471308 creator A5029896931 @default.
• W2891471308 creator A5035676212 @default.
• W2891471308 creator A5061269444 @default.
• W2891471308 creator A5076315257 @default.
• W2891471308 date "2018-09-10" @default.
• W2891471308 modified "2023-10-15" @default.
• W2891471308 title "Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome†" @default.
• W2891471308 cites W1577577364 @default.
• W2891471308 cites W1642366747 @default.
• W2891471308 cites W1972094156 @default.
• W2891471308 cites W1973557693 @default.
• W2891471308 cites W1975041988 @default.
• W2891471308 cites W1977390828 @default.
• W2891471308 cites W1978769451 @default.
• W2891471308 cites W1991981288 @default.
• W2891471308 cites W2003467497 @default.
• W2891471308 cites W2006082797 @default.
• W2891471308 cites W2011916425 @default.
• W2891471308 cites W2023206550 @default.
• W2891471308 cites W2024925103 @default.
• W2891471308 cites W2028885049 @default.
• W2891471308 cites W2038780284 @default.
• W2891471308 cites W2042114928 @default.
• W2891471308 cites W2044037816 @default.
• W2891471308 cites W2053387216 @default.
• W2891471308 cites W2065052724 @default.
• W2891471308 cites W2076248918 @default.
• W2891471308 cites W2077322831 @default.
• W2891471308 cites W2082208424 @default.
• W2891471308 cites W2085008263 @default.
• W2891471308 cites W2090141021 @default.
• W2891471308 cites W2092684025 @default.
• W2891471308 cites W2093278154 @default.
• W2891471308 cites W2095701213 @default.
• W2891471308 cites W2097560466 @default.
• W2891471308 cites W2098070096 @default.
• W2891471308 cites W2098331502 @default.
• W2891471308 cites W2101489471 @default.
• W2891471308 cites W2102278945 @default.
• W2891471308 cites W2104158422 @default.
• W2891471308 cites W2108628595 @default.
• W2891471308 cites W2112058982 @default.
• W2891471308 cites W2114788769 @default.
• W2891471308 cites W2115254115 @default.
• W2891471308 cites W2117371378 @default.
• W2891471308 cites W2118742454 @default.
• W2891471308 cites W2119715474 @default.
• W2891471308 cites W2120171525 @default.
• W2891471308 cites W2120421622 @default.
• W2891471308 cites W2122061266 @default.
• W2891471308 cites W2122062731 @default.
• W2891471308 cites W2122385301 @default.
• W2891471308 cites W2122884201 @default.
• W2891471308 cites W2122995807 @default.
• W2891471308 cites W2123790030 @default.
• W2891471308 cites W2125682554 @default.
• W2891471308 cites W2126336605 @default.
• W2891471308 cites W2127542959 @default.
• W2891471308 cites W2128890381 @default.
• W2891471308 cites W2130392841 @default.
• W2891471308 cites W2134753271 @default.
• W2891471308 cites W2136687258 @default.
• W2891471308 cites W2136960342 @default.
• W2891471308 cites W2137437233 @default.
• W2891471308 cites W2137999399 @default.
• W2891471308 cites W2138207763 @default.
• W2891471308 cites W2138581811 @default.
• W2891471308 cites W2139185718 @default.
• W2891471308 cites W2141252904 @default.
• W2891471308 cites W2143699233 @default.
• W2891471308 cites W2143881980 @default.
• W2891471308 cites W2150486267 @default.
• W2891471308 cites W2151219341 @default.
• W2891471308 cites W2153214140 @default.
• W2891471308 cites W2156232698 @default.
• W2891471308 cites W2156278938 @default.
• W2891471308 cites W2158217645 @default.
• W2891471308 cites W2160307227 @default.
• W2891471308 cites W2163350781 @default.
• W2891471308 cites W2165741891 @default.
• W2891471308 cites W2170424280 @default.
• W2891471308 cites W2170688570 @default.
• W2891471308 cites W2170717683 @default.
• W2891471308 cites W2171383527 @default.
• W2891471308 cites W2176130091 @default.
• W2891471308 cites W2305770498 @default.
• W2891471308 cites W2308008356 @default.
• W2891471308 cites W2312349741 @default.
• W2891471308 cites W2337665072 @default.
• W2891471308 cites W2400783197 @default.
• W2891471308 cites W2475779530 @default.
• W2891471308 cites W2486722724 @default.
• W2891471308 cites W2519098263 @default.

• next