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• W2891473286 abstract "Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with larotrectinib-the first selective pan-TRK inhibitor in clinical development. This 3-year-old girl had failed multiple therapies including chemotherapy and radiotherapy. Tumour profiling confirmed an ETV6-NTRK3 fusion. Treatment with larotrectinib led to rapid clinical improvement with near total resolution of primary and metastatic lesions on MRI imaging. This is the first report of a TRK fusion glioma successfully treated with a TRK inhibitor." @default.
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• W2891473286 date "2018-09-01" @default.
• W2891473286 modified "2023-10-08" @default.
• W2891473286 title "Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma" @default.
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• W2891473286 doi "https://doi.org/10.1038/s41416-018-0251-2" @default.
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