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• W2891474507 abstract "The aim of this study was to evaluate the cytotoxicity and antileishmanial activity of cisplatin-bonded carbon nanotubes both against promastigotes and amastigotes of Leishmania major in vitro. Cisplatin-bonded single-walled carbon nanotubes (CP-SWCNT) and cisplatin-bonded multi-walled carbon nanotubes (CP-MWCNT) were considered as test compounds. In addition, SWCNT, MWCNT, free cisplatin and meglumine antimoniate (Glucantime®) were considered as controls. The effect of each compound was evaluated both on promastigote and amastigote stages of L. major and the results were compared. There was a statistically significant difference between the half-maximal inhibitory concentration (IC50) of CP-SWCNT and each of the controls, including SWCNT, cisplatin and Glucantime® (P < 0.05). In addition, IC50 values of CP-MWCNT and each of the controls, including MWCNT, cisplatin and Glucantime®, were significantly different both for promastigotes and amastigotes (P < 0.05). However, the selectivity index (SI) of CP-SWCNT was <10 (5.23), indicating that this compound is not completely safe. Moreover, the SI values of CP-MWCNT (12.54) and Glucantime® (16.28) were >10, indicating the selective effect of these two compounds on the parasite. Moreover, the IC50 of CP-MWCNT (0.11 ± 0.09 μM) for amastigotes was 41-fold lower than that of Glucantime® (4.52 ± 1.31 μM), suggesting that a lower dose of CP-MWCNT in comparison with Glucantime® is required to kill 50% of amastigotes. According to the potent in vitro antileishmanial activity of CP-MWCNT at low concentration against L. major, we suggest that they are evaluated in an animal model." @default.
• W2891474507 created "2018-09-27" @default.
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• W2891474507 date "2019-03-01" @default.
• W2891474507 modified "2023-10-12" @default.
• W2891474507 title "Potent in vitro antileishmanial activity of a nanoformulation of cisplatin with carbon nanotubes against Leishmania major" @default.
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• W2891474507 doi "https://doi.org/10.1016/j.jgar.2018.09.004" @default.
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• W2891474507 hasPublicationYear "2019" @default.
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