Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891479850> ?p ?o ?g. }
- W2891479850 endingPage "e0198160" @default.
- W2891479850 startingPage "e0198160" @default.
- W2891479850 abstract "Aims This retrospective cohort study investigated whether clinical inertia, the failure to intensify treatment when required, exists in Japanese clinical practice, using the CoDiC® database. How and when patients with type 2 diabetes treated with basal insulin received treatment intensification was also described. Materials and methods Patients with type 2 diabetes who initiated basal insulin between 2004 and 2011 were eligible for inclusion. Patients with an HbA1c ≥7.0% (≥53.0 mmol/mol) after 180 days of basal insulin titration were eligible for intensification, and their treatment was followed for up to 1.5 years. Endpoints were time to intensification, changes in HbA1c, and insulin dose. Results Overall, 2351 patients initiated basal insulin treatment (mean HbA1c 9.4% [79.2 mmol/mol]), and 1279 patients were eligible for treatment intensification (HbA1c ≥7.0% [≥53.0 mmol/mol]) after the 180-day titration period. During the 1.5-year follow-up period (beyond the 180-day titration period), 270 (21%) of these patients received treatment intensification. In patients receiving treatment intensification, mean HbA1c decreased from 8.6 to 8.2% (70.5 to 66.1 mmol/mol) at end of follow-up. Treatment was intensified using bolus insulin in 126 (47%) patients and with premixed insulin in 144 (53%) patients. The estimated probability of intensifying treatment during the 12 months after recording HbA1c ≥7.0% (≥53.0 mmol/mol) was 22.8%, and 27.5% after 17 months. Mean end-of-follow-up daily insulin dose was 35.11 units for basal–bolus compared with 20.70 units for premix therapy. Conclusions This study suggests clinical inertia exists in basal insulin-treated patients with type 2 diabetes in Japan. Strategies are needed to increase the number of patients undergoing therapy intensification and to reduce the delay in intensification in Japan." @default.
- W2891479850 created "2018-09-27" @default.
- W2891479850 creator A5021646512 @default.
- W2891479850 creator A5047045330 @default.
- W2891479850 creator A5055599195 @default.
- W2891479850 creator A5063103432 @default.
- W2891479850 creator A5064954760 @default.
- W2891479850 creator A5080220465 @default.
- W2891479850 creator A5082898958 @default.
- W2891479850 date "2018-09-18" @default.
- W2891479850 modified "2023-10-16" @default.
- W2891479850 title "Clinical inertia in basal insulin-treated patients with type 2 diabetes – Results from a retrospective database study in Japan (JDDM 43)" @default.
- W2891479850 cites W1613501644 @default.
- W2891479850 cites W172609984 @default.
- W2891479850 cites W1964959186 @default.
- W2891479850 cites W1986550531 @default.
- W2891479850 cites W1992753954 @default.
- W2891479850 cites W1997746831 @default.
- W2891479850 cites W2012125528 @default.
- W2891479850 cites W2052793443 @default.
- W2891479850 cites W2065380980 @default.
- W2891479850 cites W2070863522 @default.
- W2891479850 cites W2088724567 @default.
- W2891479850 cites W2097269681 @default.
- W2891479850 cites W2101508556 @default.
- W2891479850 cites W2105744242 @default.
- W2891479850 cites W2123946565 @default.
- W2891479850 cites W2128050336 @default.
- W2891479850 cites W2134797543 @default.
- W2891479850 cites W2156990409 @default.
- W2891479850 cites W2160088494 @default.
- W2891479850 cites W2171294019 @default.
- W2891479850 cites W2226954704 @default.
- W2891479850 doi "https://doi.org/10.1371/journal.pone.0198160" @default.
- W2891479850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143196" @default.
- W2891479850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30226870" @default.
- W2891479850 hasPublicationYear "2018" @default.
- W2891479850 type Work @default.
- W2891479850 sameAs 2891479850 @default.
- W2891479850 citedByCount "15" @default.
- W2891479850 countsByYear W28914798502019 @default.
- W2891479850 countsByYear W28914798502020 @default.
- W2891479850 countsByYear W28914798502021 @default.
- W2891479850 countsByYear W28914798502022 @default.
- W2891479850 countsByYear W28914798502023 @default.
- W2891479850 crossrefType "journal-article" @default.
- W2891479850 hasAuthorship W2891479850A5021646512 @default.
- W2891479850 hasAuthorship W2891479850A5047045330 @default.
- W2891479850 hasAuthorship W2891479850A5055599195 @default.
- W2891479850 hasAuthorship W2891479850A5063103432 @default.
- W2891479850 hasAuthorship W2891479850A5064954760 @default.
- W2891479850 hasAuthorship W2891479850A5080220465 @default.
- W2891479850 hasAuthorship W2891479850A5082898958 @default.
- W2891479850 hasBestOaLocation W28914798501 @default.
- W2891479850 hasConcept C126322002 @default.
- W2891479850 hasConcept C134018914 @default.
- W2891479850 hasConcept C141071460 @default.
- W2891479850 hasConcept C167135981 @default.
- W2891479850 hasConcept C2777180221 @default.
- W2891479850 hasConcept C2778024521 @default.
- W2891479850 hasConcept C2779306644 @default.
- W2891479850 hasConcept C2781232474 @default.
- W2891479850 hasConcept C2909524832 @default.
- W2891479850 hasConcept C43376680 @default.
- W2891479850 hasConcept C555293320 @default.
- W2891479850 hasConcept C71924100 @default.
- W2891479850 hasConcept C90924648 @default.
- W2891479850 hasConceptScore W2891479850C126322002 @default.
- W2891479850 hasConceptScore W2891479850C134018914 @default.
- W2891479850 hasConceptScore W2891479850C141071460 @default.
- W2891479850 hasConceptScore W2891479850C167135981 @default.
- W2891479850 hasConceptScore W2891479850C2777180221 @default.
- W2891479850 hasConceptScore W2891479850C2778024521 @default.
- W2891479850 hasConceptScore W2891479850C2779306644 @default.
- W2891479850 hasConceptScore W2891479850C2781232474 @default.
- W2891479850 hasConceptScore W2891479850C2909524832 @default.
- W2891479850 hasConceptScore W2891479850C43376680 @default.
- W2891479850 hasConceptScore W2891479850C555293320 @default.
- W2891479850 hasConceptScore W2891479850C71924100 @default.
- W2891479850 hasConceptScore W2891479850C90924648 @default.
- W2891479850 hasIssue "9" @default.
- W2891479850 hasLocation W28914798501 @default.
- W2891479850 hasLocation W28914798502 @default.
- W2891479850 hasLocation W28914798503 @default.
- W2891479850 hasLocation W28914798504 @default.
- W2891479850 hasLocation W28914798505 @default.
- W2891479850 hasOpenAccess W2891479850 @default.
- W2891479850 hasPrimaryLocation W28914798501 @default.
- W2891479850 hasRelatedWork W1964050512 @default.
- W2891479850 hasRelatedWork W2255784306 @default.
- W2891479850 hasRelatedWork W2302924012 @default.
- W2891479850 hasRelatedWork W2464240231 @default.
- W2891479850 hasRelatedWork W2777315381 @default.
- W2891479850 hasRelatedWork W3067798487 @default.
- W2891479850 hasRelatedWork W3217278874 @default.
- W2891479850 hasRelatedWork W4229364364 @default.
- W2891479850 hasRelatedWork W4229367634 @default.
- W2891479850 hasRelatedWork W4235685257 @default.