FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891480596> ?p ?o ?g. }

• W2891480596 endingPage "106" @default.
• W2891480596 startingPage "106" @default.
• W2891480596 abstract "Background: In traditional Chinese medicine, the Shugan-Jianpi recipe is often used in the treatment of nonalcoholic fatty liver disease (NAFLD). This study aimed to explore the mechanism of the Shugan-Jianpi recipe in relation to rats with NAFLD induced by a high-fat diet. Methods: Rats were randomly divided into eight groups: normal group (NG), model group (MG), low-dose Chaihu–Shugan–San group (L-CG), high-dose Chaihu–Shugan–San group (H-CG), low-dose Shenling–Baizhu–San group (L-SG), high-dose Shenling–Baizhu–San group (H-SG), low dose of integrated-recipes group (L-IG), and high dose of integrated-recipes group (H-IG). After 26 weeks, a lipid profile, aspartate, and alanine aminotransferases in serum were detected. The serum levels of inflammatory factors including interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) were analyzed using the enzyme linked immunosorbent assay (ELISA) method. Hepatic pathological changes were observed with hematoxylin-eosin (HE) and oil red O staining. The expression of the p38 mitogen-activated protein kinases (MAPK)/nuclear factor-κB (NF-κB) pathway was detected by quantitative real-time PCR and Western blotting. Results: A pathological section revealed that NAFLD rats have been successfully reproduced. Compared with the model group, each treatment group had different degrees of improvement. The Shugan-Jianpi recipe can inhibit the serum levels of IL-1β, IL-6, and TNF-α in NAFLD rats. The expression of mRNA and a protein related to the p38 MAPK/NF-κB signaling pathway were markedly decreased as a result of the Shugan-Jianpi recipe. Conclusions: The Shugan-Jianpi recipe could attenuate NAFLD progression, and its mechanism may be related to the suppression of the p38 MAPK/NF-κB signaling pathway in hepatocytes." @default.
• W2891480596 created "2018-09-27" @default.
• W2891480596 creator A5002076658 @default.
• W2891480596 creator A5011681206 @default.
• W2891480596 creator A5033020983 @default.
• W2891480596 creator A5048709181 @default.
• W2891480596 creator A5052639870 @default.
• W2891480596 creator A5053453471 @default.
• W2891480596 creator A5061859551 @default.
• W2891480596 creator A5083302588 @default.
• W2891480596 date "2018-09-19" @default.
• W2891480596 modified "2023-10-18" @default.
• W2891480596 title "Effects of Shugan-Jianpi Recipe on the Expression of the p38 MAPK/NF-κB Signaling Pathway in the Hepatocytes of NAFLD Rats" @default.
• W2891480596 cites W1784370615 @default.
• W2891480596 cites W1975022233 @default.
• W2891480596 cites W1976777085 @default.
• W2891480596 cites W2074280894 @default.
• W2891480596 cites W2081829771 @default.
• W2891480596 cites W2088384865 @default.
• W2891480596 cites W2088854517 @default.
• W2891480596 cites W2089710705 @default.
• W2891480596 cites W2115957809 @default.
• W2891480596 cites W2117419377 @default.
• W2891480596 cites W2210672989 @default.
• W2891480596 cites W2275879522 @default.
• W2891480596 cites W2345804659 @default.
• W2891480596 cites W2509350787 @default.
• W2891480596 cites W2616297593 @default.
• W2891480596 cites W2736346397 @default.
• W2891480596 cites W2766199515 @default.
• W2891480596 doi "https://doi.org/10.3390/medicines5030106" @default.
• W2891480596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163402" @default.
• W2891480596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235843" @default.
• W2891480596 hasPublicationYear "2018" @default.
• W2891480596 type Work @default.
• W2891480596 sameAs 2891480596 @default.
• W2891480596 citedByCount "15" @default.
• W2891480596 countsByYear W28914805962019 @default.
• W2891480596 countsByYear W28914805962020 @default.
• W2891480596 countsByYear W28914805962021 @default.
• W2891480596 countsByYear W28914805962022 @default.
• W2891480596 countsByYear W28914805962023 @default.
• W2891480596 crossrefType "journal-article" @default.
• W2891480596 hasAuthorship W2891480596A5002076658 @default.
• W2891480596 hasAuthorship W2891480596A5011681206 @default.
• W2891480596 hasAuthorship W2891480596A5033020983 @default.
• W2891480596 hasAuthorship W2891480596A5048709181 @default.
• W2891480596 hasAuthorship W2891480596A5052639870 @default.
• W2891480596 hasAuthorship W2891480596A5053453471 @default.
• W2891480596 hasAuthorship W2891480596A5061859551 @default.
• W2891480596 hasAuthorship W2891480596A5083302588 @default.
• W2891480596 hasBestOaLocation W28914805961 @default.
• W2891480596 hasConcept C104317684 @default.
• W2891480596 hasConcept C125473707 @default.
• W2891480596 hasConcept C126322002 @default.
• W2891480596 hasConcept C134018914 @default.
• W2891480596 hasConcept C142724271 @default.
• W2891480596 hasConcept C17991360 @default.
• W2891480596 hasConcept C184235292 @default.
• W2891480596 hasConcept C188947578 @default.
• W2891480596 hasConcept C204232928 @default.
• W2891480596 hasConcept C204787440 @default.
• W2891480596 hasConcept C2776954865 @default.
• W2891480596 hasConcept C2778606649 @default.
• W2891480596 hasConcept C2778772119 @default.
• W2891480596 hasConcept C2779134260 @default.
• W2891480596 hasConcept C2992872382 @default.
• W2891480596 hasConcept C51551487 @default.
• W2891480596 hasConcept C55493867 @default.
• W2891480596 hasConcept C57074206 @default.
• W2891480596 hasConcept C71924100 @default.
• W2891480596 hasConcept C85265743 @default.
• W2891480596 hasConcept C86803240 @default.
• W2891480596 hasConcept C98274493 @default.
• W2891480596 hasConceptScore W2891480596C104317684 @default.
• W2891480596 hasConceptScore W2891480596C125473707 @default.
• W2891480596 hasConceptScore W2891480596C126322002 @default.
• W2891480596 hasConceptScore W2891480596C134018914 @default.
• W2891480596 hasConceptScore W2891480596C142724271 @default.
• W2891480596 hasConceptScore W2891480596C17991360 @default.
• W2891480596 hasConceptScore W2891480596C184235292 @default.
• W2891480596 hasConceptScore W2891480596C188947578 @default.
• W2891480596 hasConceptScore W2891480596C204232928 @default.
• W2891480596 hasConceptScore W2891480596C204787440 @default.
• W2891480596 hasConceptScore W2891480596C2776954865 @default.
• W2891480596 hasConceptScore W2891480596C2778606649 @default.
• W2891480596 hasConceptScore W2891480596C2778772119 @default.
• W2891480596 hasConceptScore W2891480596C2779134260 @default.
• W2891480596 hasConceptScore W2891480596C2992872382 @default.
• W2891480596 hasConceptScore W2891480596C51551487 @default.
• W2891480596 hasConceptScore W2891480596C55493867 @default.
• W2891480596 hasConceptScore W2891480596C57074206 @default.
• W2891480596 hasConceptScore W2891480596C71924100 @default.
• W2891480596 hasConceptScore W2891480596C85265743 @default.
• W2891480596 hasConceptScore W2891480596C86803240 @default.
• W2891480596 hasConceptScore W2891480596C98274493 @default.
• W2891480596 hasFunder F4320321001 @default.
• W2891480596 hasIssue "3" @default.

• next