FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891482452> ?p ?o ?g. }

• W2891482452 endingPage "413" @default.
• W2891482452 startingPage "405" @default.
• W2891482452 abstract "Phosphoinositide 3-kinase δ (PI3Kδ) is a lipid kinase involved in leukocyte recruitment and activation. Activation of PI3Kδ has been linked to airway inflammation and asthma pathogenesis. This randomized, double-blind, placebo-controlled, crossover study investigated the efficacy, safety, tolerability, and pharmacokinetics of a PI3Kδ inhibitor, nemiralisib (GSK2269557), in patients with persistent, uncontrolled asthma. Patients (n = 50) received once-daily inhaled nemiralisib (1000 µg) or placebo for 28 days, with a crossover to the alternative treatment following a 4-week washout period. Spirometry demonstrated no discernible difference in trough forced expiratory volume in 1 second (FEV1) from baseline (adjusted posterior median 7 ml; 95% credible interval -83, 102 ml) between nemiralisib and placebo treatment at day 28 (primary endpoint). These results were supported by most secondary endpoints, including weighted mean FEV1 (0-4 hours) and change in trough forced vital capacity at day 28. Nemiralisib was generally well-tolerated, with few side effects except for post-inhalation cough (nemiralisib: 35%; placebo: 9%). At day 14, sputum interleukin (IL)-5, IL-13, IL-6, and IL-8 levels were reduced by a median of 17%, 7%, 15%, and 8%, respectively, when comparing nemiralisib with placebo [n = 15 (IL-5, IL-8) or 16 (IL-6, IL-13); posterior probability of a true ratio >0%: 78%, 64%, 76%, and 63%, respectively]. These results suggest that nemiralisib inhibited PI3Kδ locally; however, this did not translate into meaningful clinical improvement. Further studies will investigate the potential efficacy of nemiralisib in patients with asthma with other specific more severe phenotypes, including those who are colonized with bacteria and frequently exacerbate." @default.
• W2891482452 created "2018-09-27" @default.
• W2891482452 creator A5002863382 @default.
• W2891482452 creator A5007691993 @default.
• W2891482452 creator A5020483459 @default.
• W2891482452 creator A5030942900 @default.
• W2891482452 creator A5034172795 @default.
• W2891482452 creator A5034193600 @default.
• W2891482452 creator A5045279412 @default.
• W2891482452 creator A5046686843 @default.
• W2891482452 creator A5047225743 @default.
• W2891482452 creator A5047250931 @default.
• W2891482452 creator A5048049198 @default.
• W2891482452 creator A5066200967 @default.
• W2891482452 creator A5072765542 @default.
• W2891482452 creator A5074110466 @default.
• W2891482452 date "2018-09-14" @default.
• W2891482452 modified "2023-09-27" @default.
• W2891482452 title "A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma" @default.
• W2891482452 cites W1135839845 @default.
• W2891482452 cites W1525326448 @default.
• W2891482452 cites W1964841658 @default.
• W2891482452 cites W1992572858 @default.
• W2891482452 cites W1995460329 @default.
• W2891482452 cites W2009993815 @default.
• W2891482452 cites W2017190378 @default.
• W2891482452 cites W2020369755 @default.
• W2891482452 cites W2039533506 @default.
• W2891482452 cites W2047633306 @default.
• W2891482452 cites W2054829155 @default.
• W2891482452 cites W2057370954 @default.
• W2891482452 cites W2070763554 @default.
• W2891482452 cites W2073808197 @default.
• W2891482452 cites W2075590458 @default.
• W2891482452 cites W2082466693 @default.
• W2891482452 cites W2103470187 @default.
• W2891482452 cites W2105173228 @default.
• W2891482452 cites W2123596413 @default.
• W2891482452 cites W2123666692 @default.
• W2891482452 cites W2125078269 @default.
• W2891482452 cites W2135431323 @default.
• W2891482452 cites W2141343329 @default.
• W2891482452 cites W2158538980 @default.
• W2891482452 cites W2163577434 @default.
• W2891482452 cites W2170148763 @default.
• W2891482452 cites W2171570378 @default.
• W2891482452 cites W2315018741 @default.
• W2891482452 cites W2416385748 @default.
• W2891482452 cites W2489914332 @default.
• W2891482452 cites W2746473595 @default.
• W2891482452 cites W2746637007 @default.
• W2891482452 cites W4211006694 @default.
• W2891482452 cites W641802818 @default.
• W2891482452 doi "https://doi.org/10.1124/jpet.118.249516" @default.
• W2891482452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30217958" @default.
• W2891482452 hasPublicationYear "2018" @default.
• W2891482452 type Work @default.
• W2891482452 sameAs 2891482452 @default.
• W2891482452 citedByCount "27" @default.
• W2891482452 countsByYear W28914824522018 @default.
• W2891482452 countsByYear W28914824522019 @default.
• W2891482452 countsByYear W28914824522020 @default.
• W2891482452 countsByYear W28914824522021 @default.
• W2891482452 countsByYear W28914824522022 @default.
• W2891482452 countsByYear W28914824522023 @default.
• W2891482452 crossrefType "journal-article" @default.
• W2891482452 hasAuthorship W2891482452A5002863382 @default.
• W2891482452 hasAuthorship W2891482452A5007691993 @default.
• W2891482452 hasAuthorship W2891482452A5020483459 @default.
• W2891482452 hasAuthorship W2891482452A5030942900 @default.
• W2891482452 hasAuthorship W2891482452A5034172795 @default.
• W2891482452 hasAuthorship W2891482452A5034193600 @default.
• W2891482452 hasAuthorship W2891482452A5045279412 @default.
• W2891482452 hasAuthorship W2891482452A5046686843 @default.
• W2891482452 hasAuthorship W2891482452A5047225743 @default.
• W2891482452 hasAuthorship W2891482452A5047250931 @default.
• W2891482452 hasAuthorship W2891482452A5048049198 @default.
• W2891482452 hasAuthorship W2891482452A5066200967 @default.
• W2891482452 hasAuthorship W2891482452A5072765542 @default.
• W2891482452 hasAuthorship W2891482452A5074110466 @default.
• W2891482452 hasBestOaLocation W28914824521 @default.
• W2891482452 hasConcept C111113717 @default.
• W2891482452 hasConcept C112705442 @default.
• W2891482452 hasConcept C126322002 @default.
• W2891482452 hasConcept C142724271 @default.
• W2891482452 hasConcept C165637977 @default.
• W2891482452 hasConcept C168563851 @default.
• W2891482452 hasConcept C197934379 @default.
• W2891482452 hasConcept C203092338 @default.
• W2891482452 hasConcept C204787440 @default.
• W2891482452 hasConcept C27081682 @default.
• W2891482452 hasConcept C2776042228 @default.
• W2891482452 hasConcept C2776954882 @default.
• W2891482452 hasConcept C2777714996 @default.
• W2891482452 hasConcept C2778375690 @default.
• W2891482452 hasConcept C2780333948 @default.
• W2891482452 hasConcept C3018587741 @default.
• W2891482452 hasConcept C42219234 @default.

• next