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- W2891486965 abstract "It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions between MAP kinase pathways and other key signalling modules. As our knowledge of the regulation, substrate specificity and catalytic mechanisms of MKPs has matured, more recent work using genetic models has revealed key physiological functions for MKPs and also uncovered potentially important roles in regulating the pathophysiological outcome of signalling with relevance to human diseases. These include cancer, diabetes, inflammatory and neurodegenerative disorders. It is hoped that this understanding will reveal novel therapeutic targets and biomarkers for disease, thus contributing to more effective diagnosis and treatment for these debilitating and often fatal conditions." @default.
- W2891486965 created "2018-09-27" @default.
- W2891486965 creator A5012008199 @default.
- W2891486965 creator A5023717901 @default.
- W2891486965 creator A5033321035 @default.
- W2891486965 date "2019-01-01" @default.
- W2891486965 modified "2023-10-11" @default.
- W2891486965 title "Dual-specificity MAP kinase phosphatases in health and disease" @default.
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