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- W2891488450 abstract "e21526 Background: Uveal melanoma is the most common malignant tumor of the eye. Metastasis occurs in about 50% of patients. With only 6 months the median survival time for patients with metastasis is very low. Thus the prognosis is poor with a 80% mortality rate after the first year. Up to now no existing treatment has been proven to extend survival for metastatic cancer. Methods: n = 14 patients with metastatic uveal melanoma were treated with a dendritic cell based immunotherapy. Dendritic cells were generated from patients own isolated monocytes using standard protocol. Survival times were calculated by Kaplan Meyer survival analysis. Results: Kaplan Meyer survival analysis shows a median overall survival after onset of DC therapy of 15 months. 71% (n = 10) of treated patients survive more than 1 year. After 2 years n = 2 patients were still alive. These two patients died of their disease after 37 and 52 months respectively. Most patients tolerate the therapy very well with only mild side effects. Conclusions: Dendritic cell therapy is well known to be effective in malignant melanoma of the skin. Here we show that a dendritic cell therapy is a successful immunotherapy in metastatic uveal melanoma inducing a prolongation of the survival when compared to historical collectives. Molecular biological analyses may further help to identify a subgroup of patients who respond to immunotherapy." @default.
- W2891488450 created "2018-09-27" @default.
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- W2891488450 date "2018-05-20" @default.
- W2891488450 modified "2023-09-26" @default.
- W2891488450 title "Dendritic cell based immunotherapy in metastatic uveal melanoma." @default.
- W2891488450 doi "https://doi.org/10.1200/jco.2018.36.15_suppl.e21526" @default.
- W2891488450 hasPublicationYear "2018" @default.
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