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- W2891490307 abstract "Intracellular pH underlies most cellular processes. There is emerging evidence of a pH-signaling role in plant cells and microorganisms. Dysregulation of pH is associated with human diseases, such as cancer and Alzheimer's disease.In this review, we attempt to provide a summary of the progress that has been made in the field during the past two decades. First, we present an overview of the current state of the design and applications of fluorescent protein (FP)-based pH indicators. Then, we turn our attention to the development and applications of hybrid pH sensors that combine the capabilities of non-GFP fluorophores with the advantages of genetically encoded tags. Finally, we discuss recent advances in multicolor pH imaging and the applications of genetically encoded pH sensors in multiparameter imaging.Genetically encoded pH sensors have proven to be indispensable noninvasive tools for selective targeting to different cellular locations. Although a variety of genetically encoded pH sensors have been designed and applied at the single cell level, there is still much room for improvements and future developments of novel powerful tools for pH imaging. Among the most pressing challenges in this area is the design of brighter redshifted sensors for tissue research and whole animal experiments.The design of precise pH measuring instruments is one of the important goals in cell biochemistry and may give rise to the development of new powerful diagnostic tools for various diseases." @default.
- W2891490307 created "2018-09-27" @default.
- W2891490307 creator A5008231898 @default.
- W2891490307 creator A5008368978 @default.
- W2891490307 creator A5010921421 @default.
- W2891490307 creator A5078789225 @default.
- W2891490307 date "2018-12-01" @default.
- W2891490307 modified "2023-09-29" @default.
- W2891490307 title "Genetically encoded fluorescent indicators for live cell pH imaging" @default.
- W2891490307 cites W1019752176 @default.
- W2891490307 cites W1158097820 @default.
- W2891490307 cites W1228585662 @default.
- W2891490307 cites W1544900705 @default.
- W2891490307 cites W1832852958 @default.
- W2891490307 cites W1963957340 @default.
- W2891490307 cites W1964314146 @default.
- W2891490307 cites W1967302106 @default.
- W2891490307 cites W1969396108 @default.
- W2891490307 cites W1970199084 @default.
- W2891490307 cites W1970270735 @default.
- W2891490307 cites W1973562367 @default.
- W2891490307 cites W1974243596 @default.
- W2891490307 cites W1974392215 @default.
- W2891490307 cites W1974642741 @default.
- W2891490307 cites W1976136773 @default.
- W2891490307 cites W1978080197 @default.
- W2891490307 cites W1978842225 @default.
- W2891490307 cites W1979073611 @default.
- W2891490307 cites W1980073547 @default.
- W2891490307 cites W1980726951 @default.
- W2891490307 cites W1982808369 @default.
- W2891490307 cites W1985013449 @default.
- W2891490307 cites W1986300566 @default.
- W2891490307 cites W1986790770 @default.
- W2891490307 cites W1988042130 @default.
- W2891490307 cites W1989230468 @default.
- W2891490307 cites W1991383594 @default.
- W2891490307 cites W1991854860 @default.
- W2891490307 cites W1995555037 @default.
- W2891490307 cites W1995702879 @default.
- W2891490307 cites W1996440573 @default.
- W2891490307 cites W1998972039 @default.
- W2891490307 cites W2002360833 @default.
- W2891490307 cites W2002694508 @default.
- W2891490307 cites W2003407164 @default.
- W2891490307 cites W2005496979 @default.
- W2891490307 cites W2006685379 @default.
- W2891490307 cites W2006842456 @default.
- W2891490307 cites W2014041054 @default.
- W2891490307 cites W2014245863 @default.
- W2891490307 cites W2015725459 @default.
- W2891490307 cites W2015794466 @default.
- W2891490307 cites W2016166286 @default.
- W2891490307 cites W2017923651 @default.
- W2891490307 cites W2018343578 @default.
- W2891490307 cites W2027631918 @default.
- W2891490307 cites W2029309165 @default.
- W2891490307 cites W2030693318 @default.
- W2891490307 cites W2030837139 @default.
- W2891490307 cites W2032860659 @default.
- W2891490307 cites W2035785520 @default.
- W2891490307 cites W2036818036 @default.
- W2891490307 cites W2039210066 @default.
- W2891490307 cites W2040048639 @default.
- W2891490307 cites W2046174774 @default.
- W2891490307 cites W2046584498 @default.
- W2891490307 cites W2048056045 @default.
- W2891490307 cites W2048722243 @default.
- W2891490307 cites W2048758396 @default.
- W2891490307 cites W2049304205 @default.
- W2891490307 cites W2050228149 @default.
- W2891490307 cites W2057315336 @default.
- W2891490307 cites W2058211348 @default.
- W2891490307 cites W2058333064 @default.
- W2891490307 cites W2061475773 @default.
- W2891490307 cites W2062764435 @default.
- W2891490307 cites W2063761428 @default.
- W2891490307 cites W2066021430 @default.
- W2891490307 cites W2066048196 @default.
- W2891490307 cites W2068050569 @default.
- W2891490307 cites W2070076684 @default.
- W2891490307 cites W2071172673 @default.
- W2891490307 cites W2077835601 @default.
- W2891490307 cites W2079531873 @default.
- W2891490307 cites W2084441235 @default.
- W2891490307 cites W2085805107 @default.
- W2891490307 cites W2086139391 @default.
- W2891490307 cites W2090212447 @default.
- W2891490307 cites W2092885604 @default.
- W2891490307 cites W2095464946 @default.
- W2891490307 cites W2098956821 @default.
- W2891490307 cites W2102914553 @default.
- W2891490307 cites W2103875213 @default.
- W2891490307 cites W2106953519 @default.
- W2891490307 cites W2107913200 @default.
- W2891490307 cites W2108854279 @default.
- W2891490307 cites W2112308680 @default.
- W2891490307 cites W2112645157 @default.