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• W2891492198 abstract "Abstract We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response." @default.
• W2891492198 created "2018-09-27" @default.
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• W2891492198 date "2018-09-17" @default.
• W2891492198 modified "2023-09-30" @default.
• W2891492198 title "G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis" @default.
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• W2891492198 doi "https://doi.org/10.1002/acn3.642" @default.
• W2891492198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186941" @default.
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