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- W2891492664 abstract "Brain organoids are an emerging technique for studying human neurodevelopment in vitro, with biomedical implications. However, three-dimensional tissue culture poses several challenges, including lack of nutrient exchange at the organoid core and limited imaging accessibility of whole organoids. Here we present a method for culturing organoids in a micro-fabricated device that enables in situ real-time imaging over weeks with efficient nutrient exchange by diffusion. Our on-chip approach offers a means for studying the dynamics of organoid development, cell differentiation, cell cycle, and motion. © 2018 by John Wiley & Sons, Inc." @default.
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- W2891492664 date "2018-09-21" @default.
- W2891492664 modified "2023-10-05" @default.
- W2891492664 title "An On-Chip Method for Long-Term Growth and Real-Time Imaging of Brain Organoids" @default.
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- W2891492664 doi "https://doi.org/10.1002/cpcb.62" @default.
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