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- W2891494723 abstract "Abstract Reversible decreases in synaptic strength, known as short-term depression (STD), are widespread in neural circuits. Various computational roles have been attributed to STD but these tend to focus upon the initial depression rather than the subsequent recovery. We studied the role of STD and recovery at an excitatory synapse between the fast extensor tibiae (FETi) and flexor tibiae (flexor) motor neurons in the desert locust ( Schistocerca gregaria ) by making paired intracellular recordings in vivo . Over behaviorally relevant pre-synaptic spike frequencies, we found that this synapse undergoes matched frequency-dependent STD and recovery; higher frequency spikes that evoke stronger, faster STD also produce stronger, faster recovery. The precise matching of depression and recovery time constants at this synapse ensures that flexor excitatory post-synaptic potential (EPSP) amplitude encodes the presynaptic FETi interspike interval (ISI). Computational modelling shows that this precise matching enables the FETi-flexor synapse to linearly encode the ISI in the EPSP amplitude, a coding strategy that may be widespread in neural circuits." @default.
- W2891494723 created "2018-09-27" @default.
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- W2891494723 date "2018-09-11" @default.
- W2891494723 modified "2023-10-12" @default.
- W2891494723 title "Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse" @default.
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- W2891494723 doi "https://doi.org/10.1038/s41598-018-31996-0" @default.
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