FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891494885> ?p ?o ?g. }

• W2891494885 abstract "Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g. thirst) and energy balance (e.g. hunger). Consumption, in turn, reinforces motivated behavior and is therefore considered rewarding. Uncovering the physiological mechanisms that underlie reinforcement and reward seeking has been particularly important in understanding health issues like obesity where individuals consume palatable, unhealthy foods beyond metabolic need. Over the years, the constructs of homeostatic (within the purview of the hypothalamus) and non-homeostatic (within the purview of mesolimbic circuitry) have been used to describe need-based versus need-free consumption. However, a growing body of literature now demonstrates that mesolimbic circuits and “higher-order” brain regions are also profoundly influenced by changes to physiological state, which in turn generate behaviors that are poised to maintain homeostasis. Mesolimbic pathways, particularly dopamine neurons of the ventral tegmental area (VTA) and their projections to nucleus accumbens (NAc), can be robustly modulated by a variety of energy balance signals, including post-ingestive feedback relaying nutrient content and hormonal signals reflecting hunger and satiety. Moreover, physiological states can also impact VTA-NAc responses to non-nutritive rewards, such as drugs of abuse. Coupled with recent evidence showing hypothalamic structures are modulated in anticipation of replenished need, the lines between circuits that convey perturbations in homeostasis and those that drive motivated behavior have been blurred. In the current review, we examine data that have revealed the importance of mesolimbic dopamine neurons and their downstream pathways as a dynamic neurobiological mechanism that provides an interface between physiological state, perturbations to homeostasis, and reward-seeking behaviors." @default.
• W2891494885 created "2018-09-27" @default.
• W2891494885 creator A5053945164 @default.
• W2891494885 creator A5079805249 @default.
• W2891494885 creator A5079934411 @default.
• W2891494885 date "2018-09-03" @default.
• W2891494885 modified "2023-09-27" @default.
• W2891494885 title "Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons" @default.
• W2891494885 cites W1036203780 @default.
• W2891494885 cites W1219461777 @default.
• W2891494885 cites W1509264826 @default.
• W2891494885 cites W1552965236 @default.
• W2891494885 cites W1579518684 @default.
• W2891494885 cites W1586056617 @default.
• W2891494885 cites W1607531583 @default.
• W2891494885 cites W1652173018 @default.
• W2891494885 cites W1717491325 @default.
• W2891494885 cites W1764998017 @default.
• W2891494885 cites W1792954972 @default.
• W2891494885 cites W1797218635 @default.
• W2891494885 cites W1814485581 @default.
• W2891494885 cites W1853541416 @default.
• W2891494885 cites W1872015020 @default.
• W2891494885 cites W1949404224 @default.
• W2891494885 cites W1963503959 @default.
• W2891494885 cites W1963823771 @default.
• W2891494885 cites W1964028898 @default.
• W2891494885 cites W1965134469 @default.
• W2891494885 cites W1965990600 @default.
• W2891494885 cites W1966233474 @default.
• W2891494885 cites W1966330898 @default.
• W2891494885 cites W1967803151 @default.
• W2891494885 cites W1968808876 @default.
• W2891494885 cites W1970545820 @default.
• W2891494885 cites W1971355682 @default.
• W2891494885 cites W1971359921 @default.
• W2891494885 cites W1971486962 @default.
• W2891494885 cites W1971623874 @default.
• W2891494885 cites W1974057366 @default.
• W2891494885 cites W1974490071 @default.
• W2891494885 cites W1974741591 @default.
• W2891494885 cites W1976648752 @default.
• W2891494885 cites W1976726492 @default.
• W2891494885 cites W1976844911 @default.
• W2891494885 cites W1977915489 @default.
• W2891494885 cites W1978259628 @default.
• W2891494885 cites W1978561086 @default.
• W2891494885 cites W1978660947 @default.
• W2891494885 cites W1978686333 @default.
• W2891494885 cites W1979173518 @default.
• W2891494885 cites W1979785761 @default.
• W2891494885 cites W1979860654 @default.
• W2891494885 cites W1979959821 @default.
• W2891494885 cites W1980207433 @default.
• W2891494885 cites W1980363663 @default.
• W2891494885 cites W1980737345 @default.
• W2891494885 cites W1980872889 @default.
• W2891494885 cites W1981025527 @default.
• W2891494885 cites W1982603796 @default.
• W2891494885 cites W1983445937 @default.
• W2891494885 cites W1984336157 @default.
• W2891494885 cites W1985548542 @default.
• W2891494885 cites W1986164891 @default.
• W2891494885 cites W1986724282 @default.
• W2891494885 cites W1987052302 @default.
• W2891494885 cites W1988112870 @default.
• W2891494885 cites W1991141677 @default.
• W2891494885 cites W1991326552 @default.
• W2891494885 cites W1993442928 @default.
• W2891494885 cites W1993838842 @default.
• W2891494885 cites W1994984635 @default.
• W2891494885 cites W1995491925 @default.
• W2891494885 cites W1997128521 @default.
• W2891494885 cites W1998274826 @default.
• W2891494885 cites W1998939463 @default.
• W2891494885 cites W2000379434 @default.
• W2891494885 cites W2001808016 @default.
• W2891494885 cites W2003982930 @default.
• W2891494885 cites W2003986105 @default.
• W2891494885 cites W2004416831 @default.
• W2891494885 cites W2006026432 @default.
• W2891494885 cites W2007161557 @default.
• W2891494885 cites W2009189044 @default.
• W2891494885 cites W2009833457 @default.
• W2891494885 cites W2009861981 @default.
• W2891494885 cites W2010610426 @default.
• W2891494885 cites W2010639796 @default.
• W2891494885 cites W2011451766 @default.
• W2891494885 cites W2013702630 @default.
• W2891494885 cites W2014321546 @default.
• W2891494885 cites W2015200492 @default.
• W2891494885 cites W2016865357 @default.
• W2891494885 cites W2017062618 @default.
• W2891494885 cites W2017423317 @default.
• W2891494885 cites W2017426660 @default.
• W2891494885 cites W2017984010 @default.
• W2891494885 cites W2021782736 @default.
• W2891494885 cites W2022366514 @default.
• W2891494885 cites W2022750583 @default.
• W2891494885 cites W2023105855 @default.

• next