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- W2891496574 abstract "Abstract Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation. Although ESCRT core components are conserved among higher eukaryotes, the regulators that control the function of the ESCRT machinery remain elusive. We recently identified a plant-specific ESCRT component, FREE1, that is essential for multivesicular body/prevacuolar compartment (MVB/PVC) biogenesis and vacuolar sorting of membrane proteins. Here we identify a plant-specific Bro1-domain protein BRAF, which regulates FREE1 recruitment to the MVB/PVC membrane by competitively binding to the ESCRT-I component Vps23. Altogether, we have successfully identified a role for BRAF, whose function as a unique evolutionary ESCRT regulator in orchestrating intraluminal vesicle formation in MVB/PVCs and the sorting of membrane proteins for degradation in plants makes it an important regulatory mechanism underlying the ESCRT machinery in higher eukaryotes." @default.
- W2891496574 created "2018-09-27" @default.
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- W2891496574 date "2018-09-17" @default.
- W2891496574 modified "2023-10-12" @default.
- W2891496574 title "A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis" @default.
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- W2891496574 doi "https://doi.org/10.1038/s41467-018-05913-y" @default.
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