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• W2891500886 startingPage "2815" @default.
• W2891500886 abstract "Protein O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) regulates many biological processes. Studies have shown that O-GlcNAc modification levels can increase during acute stress and suggested that this may contribute to the survival of the cell. This study investigated the possible effects of O-GlcNAcylation that regulate glucose metabolism, apoptosis, and autophagy in the liver after acute cold stress. Male C57BL/6 mice were exposed to cold conditions (4 °C) for 0, 2, 4, and 6 h, then their livers were extracted and the expression of proteins involved in glucose metabolism, apoptosis, and autophagy was determined. It was found that acute cold stress increased global O-GlcNAcylation and protein kinase B (AKT) phosphorylation levels. This was accompanied by significantly increased activation levels of the glucose metabolism regulators 160 kDa AKT substrate (AS160), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), and glycogen synthase kinase-3β (GSK3β). The levels of glycolytic intermediates, fructose-1,6-diphosphate (FDP) and pyruvic acid (PA), were found to show a brief increase followed by a sharp decrease. Additionally, adenosine triphosphate (ATP), as the main cellular energy source, had a sharp increase. Furthermore, the B-cell lymphoma 2(Bcl-2)/Bcl-2-associated X (Bax) ratio was found to increase, whereas cysteine-aspartic acid protease 3 (caspase-3) and light chain 3-II (LC3-II) levels were reduced after acute cold stress. Therefore, acute cold stress was found to increase O-GlcNAc modification levels, which may have resulted in the decrease of the essential processes of apoptosis and autophagy, promoting cell survival, while altering glycose transport, glycogen synthesis, and glycolysis in the liver." @default.
• W2891500886 created "2018-09-27" @default.
• W2891500886 creator A5012030584 @default.
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• W2891500886 date "2018-09-18" @default.
• W2891500886 modified "2023-09-30" @default.
• W2891500886 title "Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice" @default.
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• W2891500886 doi "https://doi.org/10.3390/ijms19092815" @default.
• W2891500886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165085" @default.
• W2891500886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30231545" @default.
• W2891500886 hasPublicationYear "2018" @default.
• W2891500886 type Work @default.
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• W2891500886 citedByCount "31" @default.

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