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- W2891508889 abstract "This chapter presents the basic concepts and mathematical relationships that predict how cocrystal solubility and thermodynamic stability change with solution conditions. It describes the key thermodynamic parameters that explain kinetic properties, which are essential to streamline cocrystal discovery and development. Multicomponent solids include crystalline and amorphous systems. Pharmaceutical cocrystals are generally characterized by hydrogen-bonded assemblies between drug and coformer molecules. The structural properties of a cocrystal and/or salt can be determined by crystallographic and spectroscopic techniques. Transition points establish conditions under which cocrystals are thermodynamically stable or unstable, or more or less soluble than drug. The chapter illustrates that cocrystal and drug solubilities are deeply influenced by solution conditions such as ionization, solubilization, and solution stoichiometry. Cocrystal formation in melts has also been used in Cocrystal screening and large-scale processes. The chapter considers the phase and chemical equilibria that give rise to cocrystal solubility and stability equations." @default.
- W2891508889 created "2018-09-27" @default.
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- W2891508889 date "2018-09-08" @default.
- W2891508889 modified "2023-10-18" @default.
- W2891508889 title "Measurement and Mathematical Relationships of Cocrystal Thermodynamic Properties" @default.
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- W2891508889 doi "https://doi.org/10.1002/9781119046233.ch6" @default.
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