Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891514368> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2891514368 endingPage "898" @default.
- W2891514368 startingPage "884" @default.
- W2891514368 abstract "Background/Aims: Periapical periodontitis is caused by bacterial infection and results in both one destruction and tooth loss. Osteopontin (OPN) is a secreted phosphorylated glycoprotein that participates in bone metabolism. Methods: Thirty-three patients with chronic periapical periodontitis and 10 patients who had undergone the orthodontic removal of healthy tooth tissue (control) at the periodontal ligament were investigated, and an animal model of mouse periapical periodontitis was established for an in vivo analysis. The relationship between OPN and bone destruction during periapical periodontitis was analyzed. Osteoblasts and osteoclasts were cultured in vitro and treated with lipopolysaccharide. An inhibitor of NF-κB was used to pretreat the transfected cells. Results: OPN increased osteoclast proliferation and differentiation, but reduced osteoblasts proliferation and differentiation. OPN activated the NF-κB pathway during periapical periodontitis and accelerated the transfer and phosphorylation of P65 from the cytoplasm to the nucleus. Conclusion: This study demonstrated that OPN played important roles in the progression of periapical periodontitis, and a dual role in bone metabolism during periapical periodontitis, linking osteoclasts and osteoblasts. The underlying mechanism may be related to the NF-κB pathway." @default.
- W2891514368 created "2018-09-27" @default.
- W2891514368 creator A5021138454 @default.
- W2891514368 creator A5028121388 @default.
- W2891514368 creator A5040289957 @default.
- W2891514368 creator A5046538435 @default.
- W2891514368 creator A5064994865 @default.
- W2891514368 creator A5068712202 @default.
- W2891514368 creator A5082543297 @default.
- W2891514368 creator A5083520305 @default.
- W2891514368 creator A5087581435 @default.
- W2891514368 date "2018-01-01" @default.
- W2891514368 modified "2023-09-27" @default.
- W2891514368 title "Osteopontin Promotes Bone Destruction in Periapical Periodontitis by Activating the NF-κB Pathway" @default.
- W2891514368 doi "https://doi.org/10.1159/000493219" @default.
- W2891514368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30184545" @default.
- W2891514368 hasPublicationYear "2018" @default.
- W2891514368 type Work @default.
- W2891514368 sameAs 2891514368 @default.
- W2891514368 citedByCount "29" @default.
- W2891514368 countsByYear W28915143682019 @default.
- W2891514368 countsByYear W28915143682020 @default.
- W2891514368 countsByYear W28915143682021 @default.
- W2891514368 countsByYear W28915143682022 @default.
- W2891514368 countsByYear W28915143682023 @default.
- W2891514368 crossrefType "journal-article" @default.
- W2891514368 hasAuthorship W2891514368A5021138454 @default.
- W2891514368 hasAuthorship W2891514368A5028121388 @default.
- W2891514368 hasAuthorship W2891514368A5040289957 @default.
- W2891514368 hasAuthorship W2891514368A5046538435 @default.
- W2891514368 hasAuthorship W2891514368A5064994865 @default.
- W2891514368 hasAuthorship W2891514368A5068712202 @default.
- W2891514368 hasAuthorship W2891514368A5082543297 @default.
- W2891514368 hasAuthorship W2891514368A5083520305 @default.
- W2891514368 hasAuthorship W2891514368A5087581435 @default.
- W2891514368 hasBestOaLocation W28915143681 @default.
- W2891514368 hasConcept C126322002 @default.
- W2891514368 hasConcept C142724271 @default.
- W2891514368 hasConcept C170033053 @default.
- W2891514368 hasConcept C170493617 @default.
- W2891514368 hasConcept C185592680 @default.
- W2891514368 hasConcept C199343813 @default.
- W2891514368 hasConcept C202751555 @default.
- W2891514368 hasConcept C203014093 @default.
- W2891514368 hasConcept C2776033226 @default.
- W2891514368 hasConcept C2778260815 @default.
- W2891514368 hasConcept C2779337755 @default.
- W2891514368 hasConcept C2780385504 @default.
- W2891514368 hasConcept C2780804394 @default.
- W2891514368 hasConcept C41868710 @default.
- W2891514368 hasConcept C502942594 @default.
- W2891514368 hasConcept C55493867 @default.
- W2891514368 hasConcept C673006 @default.
- W2891514368 hasConcept C71924100 @default.
- W2891514368 hasConceptScore W2891514368C126322002 @default.
- W2891514368 hasConceptScore W2891514368C142724271 @default.
- W2891514368 hasConceptScore W2891514368C170033053 @default.
- W2891514368 hasConceptScore W2891514368C170493617 @default.
- W2891514368 hasConceptScore W2891514368C185592680 @default.
- W2891514368 hasConceptScore W2891514368C199343813 @default.
- W2891514368 hasConceptScore W2891514368C202751555 @default.
- W2891514368 hasConceptScore W2891514368C203014093 @default.
- W2891514368 hasConceptScore W2891514368C2776033226 @default.
- W2891514368 hasConceptScore W2891514368C2778260815 @default.
- W2891514368 hasConceptScore W2891514368C2779337755 @default.
- W2891514368 hasConceptScore W2891514368C2780385504 @default.
- W2891514368 hasConceptScore W2891514368C2780804394 @default.
- W2891514368 hasConceptScore W2891514368C41868710 @default.
- W2891514368 hasConceptScore W2891514368C502942594 @default.
- W2891514368 hasConceptScore W2891514368C55493867 @default.
- W2891514368 hasConceptScore W2891514368C673006 @default.
- W2891514368 hasConceptScore W2891514368C71924100 @default.
- W2891514368 hasIssue "3" @default.
- W2891514368 hasLocation W28915143681 @default.
- W2891514368 hasLocation W28915143682 @default.
- W2891514368 hasOpenAccess W2891514368 @default.
- W2891514368 hasPrimaryLocation W28915143681 @default.
- W2891514368 hasRelatedWork W1580240627 @default.
- W2891514368 hasRelatedWork W1905246266 @default.
- W2891514368 hasRelatedWork W1945451862 @default.
- W2891514368 hasRelatedWork W1979832926 @default.
- W2891514368 hasRelatedWork W2051559976 @default.
- W2891514368 hasRelatedWork W2149402451 @default.
- W2891514368 hasRelatedWork W2160098526 @default.
- W2891514368 hasRelatedWork W2385079272 @default.
- W2891514368 hasRelatedWork W2891514368 @default.
- W2891514368 hasRelatedWork W3171930456 @default.
- W2891514368 hasVolume "49" @default.
- W2891514368 isParatext "false" @default.
- W2891514368 isRetracted "false" @default.
- W2891514368 magId "2891514368" @default.
- W2891514368 workType "article" @default.