FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891517856> ?p ?o ?g. }

• W2891517856 endingPage "315" @default.
• W2891517856 startingPage "304" @default.
• W2891517856 abstract "Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099. Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system. SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8+IFN-γ+ T cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and anti-PD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growth in two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy." @default.
• W2891517856 created "2018-09-27" @default.
• W2891517856 creator A5001969147 @default.
• W2891517856 creator A5005353168 @default.
• W2891517856 creator A5006890585 @default.
• W2891517856 creator A5007682162 @default.
• W2891517856 creator A5015730356 @default.
• W2891517856 creator A5019005101 @default.
• W2891517856 creator A5022249662 @default.
• W2891517856 creator A5038755507 @default.
• W2891517856 creator A5045336307 @default.
• W2891517856 creator A5051147169 @default.
• W2891517856 creator A5059709873 @default.
• W2891517856 creator A5060424374 @default.
• W2891517856 creator A5072576749 @default.
• W2891517856 creator A5087388855 @default.
• W2891517856 date "2019-03-01" @default.
• W2891517856 modified "2023-10-17" @default.
• W2891517856 title "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" @default.
• W2891517856 cites W1674292201 @default.
• W2891517856 cites W1881020575 @default.
• W2891517856 cites W1930287693 @default.
• W2891517856 cites W1971697388 @default.
• W2891517856 cites W1986755373 @default.
• W2891517856 cites W1999686120 @default.
• W2891517856 cites W2002444372 @default.
• W2891517856 cites W2057985962 @default.
• W2891517856 cites W2066671159 @default.
• W2891517856 cites W2082289040 @default.
• W2891517856 cites W2090695896 @default.
• W2891517856 cites W2107556275 @default.
• W2891517856 cites W2121227637 @default.
• W2891517856 cites W2126259300 @default.
• W2891517856 cites W2130473166 @default.
• W2891517856 cites W2130526419 @default.
• W2891517856 cites W2140875987 @default.
• W2891517856 cites W2146774792 @default.
• W2891517856 cites W2147132132 @default.
• W2891517856 cites W2148748469 @default.
• W2891517856 cites W2154923100 @default.
• W2891517856 cites W2172537925 @default.
• W2891517856 cites W2311739205 @default.
• W2891517856 cites W2419558500 @default.
• W2891517856 cites W2468923062 @default.
• W2891517856 cites W2475259576 @default.
• W2891517856 cites W2560367415 @default.
• W2891517856 cites W2560814620 @default.
• W2891517856 cites W2592133876 @default.
• W2891517856 cites W2593111137 @default.
• W2891517856 cites W2610248674 @default.
• W2891517856 cites W2766483656 @default.
• W2891517856 cites W2790752413 @default.
• W2891517856 cites W2795494304 @default.
• W2891517856 cites W2803222616 @default.
• W2891517856 cites W2804804971 @default.
• W2891517856 cites W2804957989 @default.
• W2891517856 doi "https://doi.org/10.1016/j.apsb.2018.08.009" @default.
• W2891517856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6437555" @default.
• W2891517856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30972278" @default.
• W2891517856 hasPublicationYear "2019" @default.
• W2891517856 type Work @default.
• W2891517856 sameAs 2891517856 @default.
• W2891517856 citedByCount "122" @default.
• W2891517856 countsByYear W28915178562019 @default.
• W2891517856 countsByYear W28915178562020 @default.
• W2891517856 countsByYear W28915178562021 @default.
• W2891517856 countsByYear W28915178562022 @default.
• W2891517856 countsByYear W28915178562023 @default.
• W2891517856 crossrefType "journal-article" @default.
• W2891517856 hasAuthorship W2891517856A5001969147 @default.
• W2891517856 hasAuthorship W2891517856A5005353168 @default.
• W2891517856 hasAuthorship W2891517856A5006890585 @default.
• W2891517856 hasAuthorship W2891517856A5007682162 @default.
• W2891517856 hasAuthorship W2891517856A5015730356 @default.
• W2891517856 hasAuthorship W2891517856A5019005101 @default.
• W2891517856 hasAuthorship W2891517856A5022249662 @default.
• W2891517856 hasAuthorship W2891517856A5038755507 @default.
• W2891517856 hasAuthorship W2891517856A5045336307 @default.
• W2891517856 hasAuthorship W2891517856A5051147169 @default.
• W2891517856 hasAuthorship W2891517856A5059709873 @default.
• W2891517856 hasAuthorship W2891517856A5060424374 @default.
• W2891517856 hasAuthorship W2891517856A5072576749 @default.
• W2891517856 hasAuthorship W2891517856A5087388855 @default.
• W2891517856 hasBestOaLocation W28915178561 @default.
• W2891517856 hasConcept C121608353 @default.
• W2891517856 hasConcept C126322002 @default.
• W2891517856 hasConcept C150903083 @default.
• W2891517856 hasConcept C154317977 @default.
• W2891517856 hasConcept C167672396 @default.
• W2891517856 hasConcept C183193105 @default.
• W2891517856 hasConcept C202751555 @default.
• W2891517856 hasConcept C203014093 @default.
• W2891517856 hasConcept C207001950 @default.
• W2891517856 hasConcept C2776062744 @default.
• W2891517856 hasConcept C2777701055 @default.
• W2891517856 hasConcept C2780380082 @default.
• W2891517856 hasConcept C2780674031 @default.
• W2891517856 hasConcept C502942594 @default.

• next