FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891517981> ?p ?o ?g. }

• W2891517981 endingPage "e13814" @default.
• W2891517981 startingPage "e13814" @default.
• W2891517981 abstract "Preeclampsia (PE), a disorder of new-onset maternal hypertension and vascular dysfunction during pregnancy, is thought to be linked to placental ischemia-induced release of prohypertensive factors and reductions of vasoprotective factors in the maternal circulation. Although markers of sympathetic nervous activity are elevated in experimental models of placental ischemia-induced hypertension and women with PE compared with their normal pregnant counterparts, the importance of adrenergic receptor signaling in the development of hypertension in PE is unknown. Therefore, we tested the hypothesis that adrenergic receptor blockade attenuates the development of placental ischemia-induced hypertension in rats. Wistar Hannover rats underwent reduced uterine perfusion pressure (RUPP) or Sham surgeries on gestational day 14. By day 19, mean arterial blood pressure (MAP) was increased in RUPP over Sham rats. Groups of RUPP and Sham pregnant rats received terazosin and propranolol (3 mg/kg per day of each via subcutaneous osmotic minipump) to block α1- and β-adrenergic receptors, respectively, beginning on gestational day 14. Adrenergic blockade significantly attenuated the development of hypertension in the RUPP rats with a slight blood pressure-lowering response in the Sham, normal pregnant rats by day 19. In conclusion, these data implicate that placental ischemia-induced hypertension involves adrenergic receptor signaling to promote increases in blood pressure during PE." @default.
• W2891517981 created "2018-09-27" @default.
• W2891517981 creator A5019558999 @default.
• W2891517981 creator A5023076666 @default.
• W2891517981 creator A5033919728 @default.
• W2891517981 creator A5082451578 @default.
• W2891517981 creator A5086563558 @default.
• W2891517981 date "2018-09-01" @default.
• W2891517981 modified "2023-10-12" @default.
• W2891517981 title "Adrenergic receptor blockade attenuates placental ischemia-induced hypertension" @default.
• W2891517981 cites W1194485173 @default.
• W2891517981 cites W139295014 @default.
• W2891517981 cites W1490814708 @default.
• W2891517981 cites W1550034218 @default.
• W2891517981 cites W1609768225 @default.
• W2891517981 cites W1909699427 @default.
• W2891517981 cites W1963940192 @default.
• W2891517981 cites W1964249453 @default.
• W2891517981 cites W1974753643 @default.
• W2891517981 cites W1987366975 @default.
• W2891517981 cites W1989203508 @default.
• W2891517981 cites W1995808650 @default.
• W2891517981 cites W2001667896 @default.
• W2891517981 cites W2019256141 @default.
• W2891517981 cites W2020512524 @default.
• W2891517981 cites W2025866667 @default.
• W2891517981 cites W2029432061 @default.
• W2891517981 cites W2038102509 @default.
• W2891517981 cites W2046241647 @default.
• W2891517981 cites W2047639390 @default.
• W2891517981 cites W2048734053 @default.
• W2891517981 cites W2053450228 @default.
• W2891517981 cites W2059647625 @default.
• W2891517981 cites W2074162473 @default.
• W2891517981 cites W2075767103 @default.
• W2891517981 cites W2077663564 @default.
• W2891517981 cites W2078232348 @default.
• W2891517981 cites W2090332907 @default.
• W2891517981 cites W2099856909 @default.
• W2891517981 cites W2100695272 @default.
• W2891517981 cites W2105311106 @default.
• W2891517981 cites W2111417603 @default.
• W2891517981 cites W2117179313 @default.
• W2891517981 cites W2118232604 @default.
• W2891517981 cites W2119567698 @default.
• W2891517981 cites W2121501560 @default.
• W2891517981 cites W2131528943 @default.
• W2891517981 cites W2133010496 @default.
• W2891517981 cites W2133309806 @default.
• W2891517981 cites W2143180984 @default.
• W2891517981 cites W2143584276 @default.
• W2891517981 cites W2149764900 @default.
• W2891517981 cites W2150768597 @default.
• W2891517981 cites W2154660919 @default.
• W2891517981 cites W2155159913 @default.
• W2891517981 cites W2156138468 @default.
• W2891517981 cites W2157381327 @default.
• W2891517981 cites W2158638253 @default.
• W2891517981 cites W2158761135 @default.
• W2891517981 cites W2160230584 @default.
• W2891517981 cites W2161470266 @default.
• W2891517981 cites W2233974801 @default.
• W2891517981 cites W2249573026 @default.
• W2891517981 cites W2251229795 @default.
• W2891517981 cites W2267669237 @default.
• W2891517981 cites W2335426572 @default.
• W2891517981 cites W2340668831 @default.
• W2891517981 cites W2340691574 @default.
• W2891517981 cites W2341237541 @default.
• W2891517981 cites W2400487578 @default.
• W2891517981 cites W2411259985 @default.
• W2891517981 cites W2414982922 @default.
• W2891517981 cites W2430003272 @default.
• W2891517981 cites W2437382798 @default.
• W2891517981 cites W2463697040 @default.
• W2891517981 cites W2469215947 @default.
• W2891517981 cites W2501632055 @default.
• W2891517981 cites W2511661905 @default.
• W2891517981 cites W2521697869 @default.
• W2891517981 cites W2533165820 @default.
• W2891517981 cites W2597572948 @default.
• W2891517981 cites W2609045225 @default.
• W2891517981 cites W2737797553 @default.
• W2891517981 cites W2746176044 @default.
• W2891517981 cites W2755022538 @default.
• W2891517981 cites W2766336794 @default.
• W2891517981 cites W2766525183 @default.
• W2891517981 cites W2783941610 @default.
• W2891517981 cites W2789258533 @default.
• W2891517981 cites W2793714854 @default.
• W2891517981 cites W2793747662 @default.
• W2891517981 cites W2797873868 @default.
• W2891517981 cites W2891517981 @default.
• W2891517981 cites W2910154696 @default.
• W2891517981 cites W301622561 @default.
• W2891517981 doi "https://doi.org/10.14814/phy2.13814" @default.
• W2891517981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6121121" @default.
• W2891517981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229567" @default.

• next