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- W2891522135 abstract "Among cationic molecules that can modulate ribozyme activities, polyamines act as both activator and inhibitor of ribozyme reactions partly due to their structural flexibility. Restriction of structural flexibility of polyamines may allow them to emphasize particular modulation effects. We examined eight stereoisomers of a synthetic pentamine bearing three cyclopentane rings. In the reaction of a structurally unstable group I ribozyme, three stereoisomers exhibited distinct effects as inhibitor, an additive with a neutral effect, and also as an activator." @default.
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- W2891522135 date "2018-10-01" @default.
- W2891522135 modified "2023-09-25" @default.
- W2891522135 title "Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural constraints" @default.
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- W2891522135 doi "https://doi.org/10.1016/j.bbrc.2018.09.015" @default.
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