Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891522602> ?p ?o ?g. }
- W2891522602 endingPage "972" @default.
- W2891522602 startingPage "965" @default.
- W2891522602 abstract "The recent dramatic increase in intentional and unintentional deaths attributed to opioids has refocused attention on the therapeutic ratio (risk-benefit ratio) of opioid analgesics. Almost all traditional opioid analgesics produce their effects (therapeutic and adverse) via the activation of μ-opioid receptor (MOR) pathways. It is therefore important to examine the question of whether this natural endogenous pathway can still be activated, but with greater safety. Areas covered: Other comprehensive reviews have focused on pharmacokinetic (e.g. peripheral restriction) and pharmacodynamic (e.g. functional selectivity, biased ligand) approaches. Herein, the authors focus on a different approach, specifically, multi-mechanistic 'atypical opioids' that synergistically combines MOR activation plus one or more non-opioid mechanism of analgesic action. Expert opinion: Four 'atypical opioid' analgesics on the market act as μ-opioid receptor pathway agonists but have a non-opioid mechanism of action that significantly contributes to the analgesic effect. The multi-mechanistic action of these products confers particular clinical utility in that they provide effective analgesia with relatively lower opioid load, and they are generally associated with fewer or less severe opioid-related adverse effects and less abuse compared to traditional opioid analgesics." @default.
- W2891522602 created "2018-09-27" @default.
- W2891522602 creator A5040109608 @default.
- W2891522602 creator A5055625141 @default.
- W2891522602 creator A5056052291 @default.
- W2891522602 creator A5056376467 @default.
- W2891522602 creator A5074172023 @default.
- W2891522602 creator A5077593052 @default.
- W2891522602 date "2018-09-03" @default.
- W2891522602 modified "2023-09-27" @default.
- W2891522602 title "Designing safer analgesics: a focus on μ-opioid receptor pathways" @default.
- W2891522602 cites W100098653 @default.
- W2891522602 cites W1555759556 @default.
- W2891522602 cites W1564287406 @default.
- W2891522602 cites W1837086671 @default.
- W2891522602 cites W1921516774 @default.
- W2891522602 cites W1945344898 @default.
- W2891522602 cites W1951897616 @default.
- W2891522602 cites W1974086725 @default.
- W2891522602 cites W1997675350 @default.
- W2891522602 cites W2002790433 @default.
- W2891522602 cites W2007440728 @default.
- W2891522602 cites W2007926571 @default.
- W2891522602 cites W2007928625 @default.
- W2891522602 cites W2010140431 @default.
- W2891522602 cites W2013718621 @default.
- W2891522602 cites W2021469789 @default.
- W2891522602 cites W2024940322 @default.
- W2891522602 cites W2036267079 @default.
- W2891522602 cites W2042386124 @default.
- W2891522602 cites W2047300693 @default.
- W2891522602 cites W2049254695 @default.
- W2891522602 cites W2052158520 @default.
- W2891522602 cites W2053473429 @default.
- W2891522602 cites W2063539450 @default.
- W2891522602 cites W2064103866 @default.
- W2891522602 cites W2066187627 @default.
- W2891522602 cites W2068240584 @default.
- W2891522602 cites W2072117854 @default.
- W2891522602 cites W2101754846 @default.
- W2891522602 cites W2109244967 @default.
- W2891522602 cites W2121230434 @default.
- W2891522602 cites W2122130641 @default.
- W2891522602 cites W2124898317 @default.
- W2891522602 cites W2127123105 @default.
- W2891522602 cites W2140288698 @default.
- W2891522602 cites W2146239445 @default.
- W2891522602 cites W2151526024 @default.
- W2891522602 cites W2152359315 @default.
- W2891522602 cites W2157999436 @default.
- W2891522602 cites W2160131914 @default.
- W2891522602 cites W2167931192 @default.
- W2891522602 cites W2282679090 @default.
- W2891522602 cites W2416363991 @default.
- W2891522602 cites W2425518107 @default.
- W2891522602 cites W2494209776 @default.
- W2891522602 cites W2499653477 @default.
- W2891522602 cites W2554311649 @default.
- W2891522602 cites W2560804566 @default.
- W2891522602 cites W2591605610 @default.
- W2891522602 cites W2598090216 @default.
- W2891522602 cites W2608917538 @default.
- W2891522602 cites W2722711213 @default.
- W2891522602 cites W2770319189 @default.
- W2891522602 cites W2779680676 @default.
- W2891522602 cites W71057974 @default.
- W2891522602 doi "https://doi.org/10.1080/17460441.2018.1511539" @default.
- W2891522602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175624" @default.
- W2891522602 hasPublicationYear "2018" @default.
- W2891522602 type Work @default.
- W2891522602 sameAs 2891522602 @default.
- W2891522602 citedByCount "29" @default.
- W2891522602 countsByYear W28915226022019 @default.
- W2891522602 countsByYear W28915226022020 @default.
- W2891522602 countsByYear W28915226022021 @default.
- W2891522602 countsByYear W28915226022022 @default.
- W2891522602 countsByYear W28915226022023 @default.
- W2891522602 crossrefType "journal-article" @default.
- W2891522602 hasAuthorship W2891522602A5040109608 @default.
- W2891522602 hasAuthorship W2891522602A5055625141 @default.
- W2891522602 hasAuthorship W2891522602A5056052291 @default.
- W2891522602 hasAuthorship W2891522602A5056376467 @default.
- W2891522602 hasAuthorship W2891522602A5074172023 @default.
- W2891522602 hasAuthorship W2891522602A5077593052 @default.
- W2891522602 hasConcept C111113717 @default.
- W2891522602 hasConcept C112705442 @default.
- W2891522602 hasConcept C126322002 @default.
- W2891522602 hasConcept C170493617 @default.
- W2891522602 hasConcept C197934379 @default.
- W2891522602 hasConcept C2779886867 @default.
- W2891522602 hasConcept C2780820201 @default.
- W2891522602 hasConcept C2781063702 @default.
- W2891522602 hasConcept C71924100 @default.
- W2891522602 hasConcept C98274493 @default.
- W2891522602 hasConceptScore W2891522602C111113717 @default.
- W2891522602 hasConceptScore W2891522602C112705442 @default.
- W2891522602 hasConceptScore W2891522602C126322002 @default.
- W2891522602 hasConceptScore W2891522602C170493617 @default.