FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891524643> ?p ?o ?g. }

• W2891524643 endingPage "383" @default.
• W2891524643 startingPage "378" @default.
• W2891524643 abstract "Tbx2 plays a critical role in determining fates of cardiomyocytes. Little is known about the contribution of TBX2 3' untranslated region (UTR) variants to the risk of congenital heart defect (CHD). Thus, we aimed to determine the association of single-nucleotide polymorphisms (SNPs) in TBX2 3' UTR with CHD susceptibility.We recruited 1285 controls and 1241 CHD children from China. SNPs identification and genotyping were detected using Sanger Sequencing and SNaPshot. Stratified analysis was conducted to explore the association between rs59382073 polymorphism and CHD subtypes. Functional analyses were performed by luciferase assays in HEK-293T and H9c2 cells.Among five TBX2 3'UTR variants identified, rs59382073 minor allele T carriers had a 1.89-fold increased CHD risk compared to GG genotype (95% CI = 1.48-2.46, P = 4.48 × 10-7). The most probable subtypes were right ventricular outflow tract obstruction, conotruncal, and septal defect. G to T variation decreased luciferase activity in cells. This discrepancy was exaggerated by miR-3940 and miR-708, while their corresponding inhibitors eliminated it.T allele of rs59382073 in TBX2 3'UTR contributed to greater CHD risk in the Han Chinese population. G to T variation created binding sites for miR-3940 and miR-708 to inhibit gene expression." @default.
• W2891524643 created "2018-09-27" @default.
• W2891524643 creator A5020238644 @default.
• W2891524643 creator A5025914436 @default.
• W2891524643 creator A5026153209 @default.
• W2891524643 creator A5041841329 @default.
• W2891524643 creator A5065058975 @default.
• W2891524643 creator A5075877965 @default.
• W2891524643 creator A5087282779 @default.
• W2891524643 creator A5089075778 @default.
• W2891524643 date "2018-09-18" @default.
• W2891524643 modified "2023-10-15" @default.
• W2891524643 title "Susceptibility to congenital heart defects associated with a polymorphism in TBX2 3′ untranslated region in the Han Chinese population" @default.
• W2891524643 cites W1974249466 @default.
• W2891524643 cites W1986727625 @default.
• W2891524643 cites W1995947612 @default.
• W2891524643 cites W2013241897 @default.
• W2891524643 cites W2023081386 @default.
• W2891524643 cites W2023299287 @default.
• W2891524643 cites W2031341812 @default.
• W2891524643 cites W2043066053 @default.
• W2891524643 cites W2045443490 @default.
• W2891524643 cites W2060092977 @default.
• W2891524643 cites W2060305085 @default.
• W2891524643 cites W2060418346 @default.
• W2891524643 cites W2068207453 @default.
• W2891524643 cites W2074775898 @default.
• W2891524643 cites W2076534900 @default.
• W2891524643 cites W2085221145 @default.
• W2891524643 cites W2087694050 @default.
• W2891524643 cites W2099928826 @default.
• W2891524643 cites W2104276565 @default.
• W2891524643 cites W2113520802 @default.
• W2891524643 cites W2127131319 @default.
• W2891524643 cites W2141804334 @default.
• W2891524643 cites W2148559371 @default.
• W2891524643 cites W2152041515 @default.
• W2891524643 cites W2155539618 @default.
• W2891524643 cites W2159459254 @default.
• W2891524643 cites W2162347038 @default.
• W2891524643 cites W2166252345 @default.
• W2891524643 cites W2254174322 @default.
• W2891524643 cites W2471160002 @default.
• W2891524643 cites W2737530623 @default.
• W2891524643 doi "https://doi.org/10.1038/s41390-018-0181-y" @default.
• W2891524643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262811" @default.
• W2891524643 hasPublicationYear "2018" @default.
• W2891524643 type Work @default.
• W2891524643 sameAs 2891524643 @default.
• W2891524643 citedByCount "4" @default.
• W2891524643 countsByYear W28915246432018 @default.
• W2891524643 countsByYear W28915246432020 @default.
• W2891524643 countsByYear W28915246432022 @default.
• W2891524643 crossrefType "journal-article" @default.
• W2891524643 hasAuthorship W2891524643A5020238644 @default.
• W2891524643 hasAuthorship W2891524643A5025914436 @default.
• W2891524643 hasAuthorship W2891524643A5026153209 @default.
• W2891524643 hasAuthorship W2891524643A5041841329 @default.
• W2891524643 hasAuthorship W2891524643A5065058975 @default.
• W2891524643 hasAuthorship W2891524643A5075877965 @default.
• W2891524643 hasAuthorship W2891524643A5087282779 @default.
• W2891524643 hasAuthorship W2891524643A5089075778 @default.
• W2891524643 hasBestOaLocation W28915246431 @default.
• W2891524643 hasConcept C104317684 @default.
• W2891524643 hasConcept C105580179 @default.
• W2891524643 hasConcept C111335760 @default.
• W2891524643 hasConcept C135763542 @default.
• W2891524643 hasConcept C153209595 @default.
• W2891524643 hasConcept C153911025 @default.
• W2891524643 hasConcept C180754005 @default.
• W2891524643 hasConcept C22667442 @default.
• W2891524643 hasConcept C31467283 @default.
• W2891524643 hasConcept C501734568 @default.
• W2891524643 hasConcept C54009773 @default.
• W2891524643 hasConcept C54355233 @default.
• W2891524643 hasConcept C71924100 @default.
• W2891524643 hasConcept C76818968 @default.
• W2891524643 hasConcept C86803240 @default.
• W2891524643 hasConcept C89604277 @default.
• W2891524643 hasConceptScore W2891524643C104317684 @default.
• W2891524643 hasConceptScore W2891524643C105580179 @default.
• W2891524643 hasConceptScore W2891524643C111335760 @default.
• W2891524643 hasConceptScore W2891524643C135763542 @default.
• W2891524643 hasConceptScore W2891524643C153209595 @default.
• W2891524643 hasConceptScore W2891524643C153911025 @default.
• W2891524643 hasConceptScore W2891524643C180754005 @default.
• W2891524643 hasConceptScore W2891524643C22667442 @default.
• W2891524643 hasConceptScore W2891524643C31467283 @default.
• W2891524643 hasConceptScore W2891524643C501734568 @default.
• W2891524643 hasConceptScore W2891524643C54009773 @default.
• W2891524643 hasConceptScore W2891524643C54355233 @default.
• W2891524643 hasConceptScore W2891524643C71924100 @default.
• W2891524643 hasConceptScore W2891524643C76818968 @default.
• W2891524643 hasConceptScore W2891524643C86803240 @default.
• W2891524643 hasConceptScore W2891524643C89604277 @default.
• W2891524643 hasIssue "3" @default.
• W2891524643 hasLocation W28915246431 @default.
• W2891524643 hasLocation W28915246432 @default.

• next